Inhibitor of Apoptosis Proteins (IAPs) are commonly dysregulated in GIST and can be pharmacologically targeted to enhance the pro-apoptotic activity of imatinib

Gastrointestinal stromal tumors (GIST) exhibit a strong oncogenic dependency on KIT and KIT inhibitors confer long lasting disease stabilization in the majority of patients. Nonetheless, KIT inhibition alone does not cure GIST as a subset of GIST cells evade apoptosis and eventually develop resistan...

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Detalles Bibliográficos
Autores principales: Falkenhorst, Johanna, Grunewald, Susanne, Mühlenberg, Thomas, Marino-Enriquez, Adrian, Reis, Anna-Carina, Corless, Christopher, Heinrich, Michael, Treckmann, Jürgen, Podleska, Lars Erik, Schuler, Martin, Fletcher, Jonathan Alfred, Bauer, Sebastian
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2016
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5173067/
https://www.ncbi.nlm.nih.gov/pubmed/27167336
http://dx.doi.org/10.18632/oncotarget.9159

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