Functional TRAIL receptors in monocytes and tumor-associated macrophages: A possible targeting pathway in the tumor microenvironment

Despite the accepted dogma that TRAIL kills only tumor cells and spares normal ones, we show in this study that mononuclear phagocytes are susceptible to recombinant TRAIL via caspase-dependent apoptosis. Human resting monocytes and in vitro-differentiated macrophages expressed substantial levels of...

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Detalles Bibliográficos
Autores principales: Liguori, Manuela, Buracchi, Chiara, Pasqualini, Fabio, Bergomas, Francesca, Pesce, Samantha, Sironi, Marina, Grizzi, Fabio, Mantovani, Alberto, Belgiovine, Cristina, Allavena, Paola
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2016
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5173086/
https://www.ncbi.nlm.nih.gov/pubmed/27191500
http://dx.doi.org/10.18632/oncotarget.9340

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