Regulation of HK2 expression through alterations in CpG methylation of the HK2 promoter during progression of hepatocellular carcinoma

Hexokinase 2 (HK2) is a rate-determining enzyme in aerobic glycolysis, a process upregulated in tumor cells. HK2 expression is controlled by various transcription factors and epigenetic alterations and is heterogeneous in hepatocellular carcinomas (HCCs), though the cause of this heterogeneity is no...

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Detalles Bibliográficos
Autores principales: Lee, Hyun Gyu, Kim, Hyemi, Son, Taekwon, Jeong, Youngtae, Kim, Seung Up, Dong, Seung Myung, Park, Young Nyun, Lee, Jong Doo, Lee, Jae Myun, Park, Jeon Han
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2016
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5173097/
https://www.ncbi.nlm.nih.gov/pubmed/27260001
http://dx.doi.org/10.18632/oncotarget.9723

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