Cargando…
Validation study for the hypothesis of internal mammary sentinel lymph node lymphatic drainage in breast cancer
According to axilla sentinel lymph node lymphatic drainage pattern, we hypothesized that internal mammary sentinel lymph node (IM-SLN) receives lymphatic drainage from not only the primary tumor area, but also the entire breast parenchyma. Based on the hypothesis a modified radiotracer injection tec...
Autores principales: | , , , , , , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Impact Journals LLC
2016
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5173111/ https://www.ncbi.nlm.nih.gov/pubmed/27248827 http://dx.doi.org/10.18632/oncotarget.9634 |
_version_ | 1782484265435398144 |
---|---|
author | Cong, Bin-Bin Qiu, Peng-Fei Liu, Yan-Bing Zhao, Tong Chen, Peng Cao, Xiao-Shan Wang, Chun-Jian Zhang, Zhao-Peng Sun, Xiao Yu, Jin-Ming Wang, Yong-Sheng |
author_facet | Cong, Bin-Bin Qiu, Peng-Fei Liu, Yan-Bing Zhao, Tong Chen, Peng Cao, Xiao-Shan Wang, Chun-Jian Zhang, Zhao-Peng Sun, Xiao Yu, Jin-Ming Wang, Yong-Sheng |
author_sort | Cong, Bin-Bin |
collection | PubMed |
description | According to axilla sentinel lymph node lymphatic drainage pattern, we hypothesized that internal mammary sentinel lymph node (IM-SLN) receives lymphatic drainage from not only the primary tumor area, but also the entire breast parenchyma. Based on the hypothesis a modified radiotracer injection technique was established and could increase the visualization rate of the IM-SLN significantly. To verify the hypothesis, two kinds of tracers were injected at different sites of breast. The radiotracer was injected with the modified technique, and the fluorescence tracer was injected in the peritumoral intra-parenchyma. The location of IM-SLN was identified by preoperative lymphoscintigraphy and intraoperative gamma probe. Then, internal mammary sentinel lymph node biopsy (IM-SLNB) was performed. The fluorescence status of IM-SLN was identified by the fluorescence imaging system. A total of 216 patients were enrolled from September 2013 to July 2015. The overall visualization rate of IM-SLN was 71.8% (155/216). The success rate of IM-SLNB was 97.3% (145/149). The radiotracer and the fluorescence tracer were identified in the same IM-SLN in 127 cases, the correlation and the agreement is significant (Case-base, r(s)=0.836, P<0.001; Kappa=0.823, P<0.001). Different tracers injected into the different sites of the intra-parenchyma reached the same IM-SLN, which demonstrates the hypothesis that IM-SLN receives the lymphatic drainage from not only the primary tumor area but also the entire breast parenchyma. |
format | Online Article Text |
id | pubmed-5173111 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2016 |
publisher | Impact Journals LLC |
record_format | MEDLINE/PubMed |
spelling | pubmed-51731112016-12-23 Validation study for the hypothesis of internal mammary sentinel lymph node lymphatic drainage in breast cancer Cong, Bin-Bin Qiu, Peng-Fei Liu, Yan-Bing Zhao, Tong Chen, Peng Cao, Xiao-Shan Wang, Chun-Jian Zhang, Zhao-Peng Sun, Xiao Yu, Jin-Ming Wang, Yong-Sheng Oncotarget Research Paper According to axilla sentinel lymph node lymphatic drainage pattern, we hypothesized that internal mammary sentinel lymph node (IM-SLN) receives lymphatic drainage from not only the primary tumor area, but also the entire breast parenchyma. Based on the hypothesis a modified radiotracer injection technique was established and could increase the visualization rate of the IM-SLN significantly. To verify the hypothesis, two kinds of tracers were injected at different sites of breast. The radiotracer was injected with the modified technique, and the fluorescence tracer was injected in the peritumoral intra-parenchyma. The location of IM-SLN was identified by preoperative lymphoscintigraphy and intraoperative gamma probe. Then, internal mammary sentinel lymph node biopsy (IM-SLNB) was performed. The fluorescence status of IM-SLN was identified by the fluorescence imaging system. A total of 216 patients were enrolled from September 2013 to July 2015. The overall visualization rate of IM-SLN was 71.8% (155/216). The success rate of IM-SLNB was 97.3% (145/149). The radiotracer and the fluorescence tracer were identified in the same IM-SLN in 127 cases, the correlation and the agreement is significant (Case-base, r(s)=0.836, P<0.001; Kappa=0.823, P<0.001). Different tracers injected into the different sites of the intra-parenchyma reached the same IM-SLN, which demonstrates the hypothesis that IM-SLN receives the lymphatic drainage from not only the primary tumor area but also the entire breast parenchyma. Impact Journals LLC 2016-05-26 /pmc/articles/PMC5173111/ /pubmed/27248827 http://dx.doi.org/10.18632/oncotarget.9634 Text en Copyright: © 2016 Cong et al. http://creativecommons.org/licenses/by/2.5/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. |
spellingShingle | Research Paper Cong, Bin-Bin Qiu, Peng-Fei Liu, Yan-Bing Zhao, Tong Chen, Peng Cao, Xiao-Shan Wang, Chun-Jian Zhang, Zhao-Peng Sun, Xiao Yu, Jin-Ming Wang, Yong-Sheng Validation study for the hypothesis of internal mammary sentinel lymph node lymphatic drainage in breast cancer |
title | Validation study for the hypothesis of internal mammary sentinel lymph node lymphatic drainage in breast cancer |
title_full | Validation study for the hypothesis of internal mammary sentinel lymph node lymphatic drainage in breast cancer |
title_fullStr | Validation study for the hypothesis of internal mammary sentinel lymph node lymphatic drainage in breast cancer |
title_full_unstemmed | Validation study for the hypothesis of internal mammary sentinel lymph node lymphatic drainage in breast cancer |
title_short | Validation study for the hypothesis of internal mammary sentinel lymph node lymphatic drainage in breast cancer |
title_sort | validation study for the hypothesis of internal mammary sentinel lymph node lymphatic drainage in breast cancer |
topic | Research Paper |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5173111/ https://www.ncbi.nlm.nih.gov/pubmed/27248827 http://dx.doi.org/10.18632/oncotarget.9634 |
work_keys_str_mv | AT congbinbin validationstudyforthehypothesisofinternalmammarysentinellymphnodelymphaticdrainageinbreastcancer AT qiupengfei validationstudyforthehypothesisofinternalmammarysentinellymphnodelymphaticdrainageinbreastcancer AT liuyanbing validationstudyforthehypothesisofinternalmammarysentinellymphnodelymphaticdrainageinbreastcancer AT zhaotong validationstudyforthehypothesisofinternalmammarysentinellymphnodelymphaticdrainageinbreastcancer AT chenpeng validationstudyforthehypothesisofinternalmammarysentinellymphnodelymphaticdrainageinbreastcancer AT caoxiaoshan validationstudyforthehypothesisofinternalmammarysentinellymphnodelymphaticdrainageinbreastcancer AT wangchunjian validationstudyforthehypothesisofinternalmammarysentinellymphnodelymphaticdrainageinbreastcancer AT zhangzhaopeng validationstudyforthehypothesisofinternalmammarysentinellymphnodelymphaticdrainageinbreastcancer AT sunxiao validationstudyforthehypothesisofinternalmammarysentinellymphnodelymphaticdrainageinbreastcancer AT yujinming validationstudyforthehypothesisofinternalmammarysentinellymphnodelymphaticdrainageinbreastcancer AT wangyongsheng validationstudyforthehypothesisofinternalmammarysentinellymphnodelymphaticdrainageinbreastcancer |