Cargando…

Pharmacological activation of FOXO3 suppresses triple-negative breast cancer in vitro and in vivo

Triple-negative breast cancer (TNBC) is the most lethal form of breast cancer. Lacking effective therapeutic options hinders treatment of TNBC. Here, we show that bepridil (BPD) and trifluoperazine (TFP), which are FDA-approved drugs for treatment of schizophrenia and angina respectively, inhibit Ak...

Descripción completa

Detalles Bibliográficos
Autores principales:	Park, See-Hyoung, Chung, Young Min, Ma, Jessica, Yang, Qin, Berek, Jonathan S., Hu, Mickey C-T.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Impact Journals LLC 2016
Materias:	Research Paper
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5173120/ https://www.ncbi.nlm.nih.gov/pubmed/27283899 http://dx.doi.org/10.18632/oncotarget.9881

Ejemplares similares

FOXO3 signalling links ATM to the p53 apoptotic pathway following DNA damage
por: Chung, Young Min, et al.
Publicado: (2012)

Reprogramming ovarian and breast cancer cells into non-cancerous cells by low-dose metformin or SN-38 through FOXO3 activation
por: Hu, Theodore, et al.
Publicado: (2014)

Methionine deprivation suppresses triple-negative breast cancer metastasis in vitro and in vivo
por: Jeon, Hyein, et al.
Publicado: (2016)

EGFR‐targeted CAR‐T cells are potent and specific in suppressing triple‐negative breast cancer both in vitro and in vivo
por: Xia, Lin, et al.
Publicado: (2020)

Auranofin displays anticancer activity against ovarian cancer cells through FOXO3 activation independent of p53
por: PARK, SEE-HYOUN G, et al.
Publicado: (2014)

In vitro antineoplastic activity in triple-negative breast cancer cell line and in vivo
por: Madeira, Klesia, et al.
Publicado: (2014)

Forkhead box transcription factor FOXO3a suppresses estrogen-dependent breast cancer cell proliferation and tumorigenesis
por: Zou, Yiyu, et al.
Publicado: (2008)

Suppression of Invasion and Metastasis of Triple-Negative Breast Cancer Lines by Pharmacological or Genetic Inhibition of Slug Activity()()()
por: Ferrari-Amorotti, Giovanna, et al.
Publicado: (2014)

Inhibition of FOXO3 Tumor Suppressor Function by βTrCP1 through Ubiquitin-Mediated Degradation in a Tumor Mouse Model
por: Tsai, Wen-Bin, et al.
Publicado: (2010)

The Shuganhuazheng Formula in Triple-Negative Breast Cancer: A Study Based on Network Pharmacology and In Vivo Experiments
por: Wang, Bo, et al.
Publicado: (2020)

In Vitro and In Vivo Effects of Docetaxel and Dasatinib in Triple-Negative Breast Cancer: A Research Study
por: Passos, Ioannis D, et al.
Publicado: (2023)

Gallotannin Imposes S Phase Arrest in Breast Cancer Cells and Suppresses the Growth of Triple-Negative Tumors In Vivo
por: Zhao, Tiejun, et al.
Publicado: (2014)

Hsa_circ_0007823 Overexpression Suppresses the Progression of Triple-Negative Breast Cancer via Regulating miR-182-5p-FOXO1 Axis
por: Yu, Jinling, et al.
Publicado: (2023)

Sensitizing tumors to anti-PD-1 therapy by promoting NK and CD8+ T cells via pharmacological activation of FOXO3
por: Chung, Young Min, et al.
Publicado: (2021)

Exploring the mechanism of an active ingredient of ginger, dihydrocapsaicin, on triple negative breast cancer based on network pharmacology and in vitro experiments
por: Luo, Liming, et al.
Publicado: (2023)

Synergistic antitumor effects of S-1 with eribulin in vitro and in vivo for triple-negative breast cancer cell lines
por: Terashima, Masato, et al.
Publicado: (2014)

c‐Src inhibitor selectively inhibits triple‐negative breast cancer overexpressed Vimentin in vitro and in vivo
por: Lou, Longquan, et al.
Publicado: (2018)

Aquaporin 1 knockdown inhibits triple-negative breast cancer cell proliferation and invasion in vitro and in vivo
por: Ji, Yinan, et al.
Publicado: (2021)

Biotinylated Polymer-Ruthenium Conjugates: In Vitro and In Vivo Studies in a Triple-Negative Breast Cancer Model
por: Côrte-Real, Leonor, et al.
Publicado: (2022)

Atovaquone Suppresses Triple-Negative Breast Tumor Growth by Reducing Immune-Suppressive Cells
por: Gupta, Nehal, et al.
Publicado: (2021)

Tumor suppressive effect of PARP1 and FOXO3A in gastric cancers and its clinical implications
por: Park, See-Hyoung, et al.
Publicado: (2015)

Temozolomide Enhances Triple-Negative Breast Cancer Virotherapy In Vitro
por: Garza-Morales, Rodolfo, et al.
Publicado: (2018)

Silver nanoparticles selectively treat triple‐negative breast cancer cells without affecting non‐malignant breast epithelial cells in vitro and in vivo
por: Swanner, Jessica, et al.
Publicado: (2019)

Autophagy inhibitor facilitates gefitinib sensitivity in vitro and in vivo by activating mitochondrial apoptosis in triple negative breast cancer
por: Liu, Zhaoyun, et al.
Publicado: (2017)

Antagonists of growth hormone-releasing hormone suppress in vivo tumor growth and gene expression in triple negative breast cancers
por: Perez, Roberto, et al.
Publicado: (2012)

Methylation Mediated Silencing of miR-155 Suppresses the Development of Preeclampsia In Vitro and In Vivo by Targeting FOXO3
por: Luo, Xiaohua, et al.
Publicado: (2022)

Anticancer Effect of Benzimidazole Derivatives, Especially Mebendazole, on Triple-Negative Breast Cancer (TNBC) and Radiotherapy-Resistant TNBC In Vivo and In Vitro
por: Choi, Hoon Sik, et al.
Publicado: (2021)

Quercetin induces apoptosis and cell cycle arrest in triple-negative breast cancer cells through modulation of Foxo3a activity
por: Nguyen, Lich Thi, et al.
Publicado: (2017)

Study on Mechanism of Yiqi Yangyin Jiedu Recipe Inhibiting Triple Negative Breast Cancer Growth: A Network Pharmacology and In Vitro Verification
por: Sun, Xin, et al.
Publicado: (2022)

Management Options in Triple-Negative Breast Cancer
por: Minami, Christina A., et al.
Publicado: (2011)

Triple Negative Breast Cancer – An Overview
por: Aysola, Kartik, et al.
Publicado: (2013)

Nucleus-enriched Ruthenium Polypyridine Complex Acts as a Potent Inhibitor to Suppress Triple-negative Breast Cancer Metastasis In vivo
por: Zhao, Xuanhao, et al.
Publicado: (2018)

Osthole inhibits triple negative breast cancer cells by suppressing STAT3
por: Dai, Xuanxuan, et al.
Publicado: (2018)

Enhanced mitochondrial fission suppresses signaling and metastasis in triple-negative breast cancer
por: Humphries, Brock A., et al.
Publicado: (2020)

Targeting PML in triple negative breast cancer elicits growth suppression and senescence
por: Arreal, Leire, et al.
Publicado: (2019)

Tiliroside suppresses triple-negative breast cancer as a multifunctional CAXII inhibitor
por: Han, Rui, et al.
Publicado: (2022)

Nanoparticles Loaded with the BET Inhibitor JQ1 Block the Growth of Triple Negative Breast Cancer Cells In Vitro and In Vivo
por: Maggisano, Valentina, et al.
Publicado: (2019)

Cyclin B2 (CCNB2) Stimulates the Proliferation of Triple-Negative Breast Cancer (TNBC) Cells In Vitro and In Vivo
por: Wu, Shuai, et al.
Publicado: (2021)

Integrated in vivo genetic and pharmacologic screening identifies co-inhibition of EGRF and ROCK as a potential treatment regimen for triple-negative breast cancer
por: Iskit, Sedef, et al.
Publicado: (2016)

The Effect of Everolimus in an In Vitro Model of Triple Negative Breast Cancer and Osteoclasts
por: Mercatali, Laura, et al.
Publicado: (2016)

Cannot write session to /tmp/vufind_sessions/sess_ve2l3ofcq3906hdaltbea92th3