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Pharmacological activation of FOXO3 suppresses triple-negative breast cancer in vitro and in vivo

Triple-negative breast cancer (TNBC) is the most lethal form of breast cancer. Lacking effective therapeutic options hinders treatment of TNBC. Here, we show that bepridil (BPD) and trifluoperazine (TFP), which are FDA-approved drugs for treatment of schizophrenia and angina respectively, inhibit Ak...

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Detalles Bibliográficos
Autores principales:	Park, See-Hyoung, Chung, Young Min, Ma, Jessica, Yang, Qin, Berek, Jonathan S., Hu, Mickey C-T.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Impact Journals LLC 2016
Materias:	Research Paper
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5173120/ https://www.ncbi.nlm.nih.gov/pubmed/27283899 http://dx.doi.org/10.18632/oncotarget.9881

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