Long-term statin use in patients with lung cancer and dyslipidemia reduces the risk of death

BACKGROUND: Clinical studies have obtained inconsistent results of statin use on cancer outcomes. This study investigated the association between statin use and lung cancer mortality. RESULTS: The use of statin decreased mortality (hazard ratio = 0.91; 95% confidence interval: 0.86–0.96; P < .01)...

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Autores principales: Huang, Wen-Yen, Li, Chia-Hsiang, Lin, Cheng-Li, Liang, Ji-An
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2016
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5173128/
https://www.ncbi.nlm.nih.gov/pubmed/27283991
http://dx.doi.org/10.18632/oncotarget.9906
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author Huang, Wen-Yen
Li, Chia-Hsiang
Lin, Cheng-Li
Liang, Ji-An
author_facet Huang, Wen-Yen
Li, Chia-Hsiang
Lin, Cheng-Li
Liang, Ji-An
author_sort Huang, Wen-Yen
collection PubMed
description BACKGROUND: Clinical studies have obtained inconsistent results of statin use on cancer outcomes. This study investigated the association between statin use and lung cancer mortality. RESULTS: The use of statin decreased mortality (hazard ratio = 0.91; 95% confidence interval: 0.86–0.96; P < .01). The patients with a high cumulative defined daily dose of statin use before lung cancer diagnosis exhibited a low risk of mortality. MATERIALS AND METHODS: We conducted a population-based case-control study of patients with dyslipidemia. Among them, 6270 had used statins for at least 3 months before lung cancer diagnosis, and 6270 had never used statins. CONCLUSIONS: We found that statin use can reduce lung cancer mortality. A further prospective study is necessary to confirm these findings.
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spelling pubmed-51731282016-12-23 Long-term statin use in patients with lung cancer and dyslipidemia reduces the risk of death Huang, Wen-Yen Li, Chia-Hsiang Lin, Cheng-Li Liang, Ji-An Oncotarget Research Paper BACKGROUND: Clinical studies have obtained inconsistent results of statin use on cancer outcomes. This study investigated the association between statin use and lung cancer mortality. RESULTS: The use of statin decreased mortality (hazard ratio = 0.91; 95% confidence interval: 0.86–0.96; P < .01). The patients with a high cumulative defined daily dose of statin use before lung cancer diagnosis exhibited a low risk of mortality. MATERIALS AND METHODS: We conducted a population-based case-control study of patients with dyslipidemia. Among them, 6270 had used statins for at least 3 months before lung cancer diagnosis, and 6270 had never used statins. CONCLUSIONS: We found that statin use can reduce lung cancer mortality. A further prospective study is necessary to confirm these findings. Impact Journals LLC 2016-06-07 /pmc/articles/PMC5173128/ /pubmed/27283991 http://dx.doi.org/10.18632/oncotarget.9906 Text en Copyright: © 2016 Huang et al. http://creativecommons.org/licenses/by/2.5/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Research Paper
Huang, Wen-Yen
Li, Chia-Hsiang
Lin, Cheng-Li
Liang, Ji-An
Long-term statin use in patients with lung cancer and dyslipidemia reduces the risk of death
title Long-term statin use in patients with lung cancer and dyslipidemia reduces the risk of death
title_full Long-term statin use in patients with lung cancer and dyslipidemia reduces the risk of death
title_fullStr Long-term statin use in patients with lung cancer and dyslipidemia reduces the risk of death
title_full_unstemmed Long-term statin use in patients with lung cancer and dyslipidemia reduces the risk of death
title_short Long-term statin use in patients with lung cancer and dyslipidemia reduces the risk of death
title_sort long-term statin use in patients with lung cancer and dyslipidemia reduces the risk of death
topic Research Paper
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5173128/
https://www.ncbi.nlm.nih.gov/pubmed/27283991
http://dx.doi.org/10.18632/oncotarget.9906
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