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PNT2258, a novel deoxyribonucleic acid inhibitor, induces cell cycle arrest and apoptosis via a distinct mechanism of action: a new class of drug for non-Hodgkin's lymphoma

Current therapy for BCL-2-associated tumors such as Non-Hodgkin Lymphomas (NHL) is inadequate. The DNAi PNT2258, a 24 base single-stranded phosphodiester DNA oligodeoxynucleotide (PNT100) encapsulated in a protective liposome, was precisely designed to treat cancers that over-express BCL-2. PNT2258...

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Detalles Bibliográficos
Autores principales:	Ebrahim, Abdul Shukkur, Kandouz, Mustapha, Liddane, Allison, Sabbagh, Hussam, Hou, Yuning, Li, Chunying, Al-Katib, Ayad
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Impact Journals LLC 2016
Materias:	Research Paper
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5173141/ https://www.ncbi.nlm.nih.gov/pubmed/27283896 http://dx.doi.org/10.18632/oncotarget.9872

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