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Feminizing Adrenocortical Carcinoma with Distinct Histopathological Findings

We herein present a 60-year-old man with adrenocortical carcinoma who had gynecomastia. An endocrinological examination revealed increased levels of serum estradiol and dehydroepiandrosterone-sulfate (DHEA-S) and reduced levels of free testosterone. Magnetic resonance imaging showed an adrenal tumor...

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Autores principales: Hatano, Masako, Takenaka, Yasuhiro, Inoue, Ikuo, Homma, Keiko, Hasegawa, Tomonobu, Sasano, Hisanobu, Awata, Takuya, Katayama, Shigehiro
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Japanese Society of Internal Medicine 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5173498/
https://www.ncbi.nlm.nih.gov/pubmed/27853073
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author Hatano, Masako
Takenaka, Yasuhiro
Inoue, Ikuo
Homma, Keiko
Hasegawa, Tomonobu
Sasano, Hisanobu
Awata, Takuya
Katayama, Shigehiro
author_facet Hatano, Masako
Takenaka, Yasuhiro
Inoue, Ikuo
Homma, Keiko
Hasegawa, Tomonobu
Sasano, Hisanobu
Awata, Takuya
Katayama, Shigehiro
author_sort Hatano, Masako
collection PubMed
description We herein present a 60-year-old man with adrenocortical carcinoma who had gynecomastia. An endocrinological examination revealed increased levels of serum estradiol and dehydroepiandrosterone-sulfate (DHEA-S) and reduced levels of free testosterone. Magnetic resonance imaging showed an adrenal tumor with heterogeneous intensity. Iodine-131 adosterol scintigraphy showed an increased uptake at the same site. Because feminizing adrenocortical carcinoma was suspected, right adrenalectomy was performed; the pathological diagnosis was adrenocortical carcinoma. The results of immunostaining indicated a virilizing tumor. Aromatase activity was identified on RT-PCR. As disorganized steroidogenesis is pathologically present in adrenocortical carcinoma, this diagnosis should be made with caution.
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spelling pubmed-51734982016-12-27 Feminizing Adrenocortical Carcinoma with Distinct Histopathological Findings Hatano, Masako Takenaka, Yasuhiro Inoue, Ikuo Homma, Keiko Hasegawa, Tomonobu Sasano, Hisanobu Awata, Takuya Katayama, Shigehiro Intern Med Case Report We herein present a 60-year-old man with adrenocortical carcinoma who had gynecomastia. An endocrinological examination revealed increased levels of serum estradiol and dehydroepiandrosterone-sulfate (DHEA-S) and reduced levels of free testosterone. Magnetic resonance imaging showed an adrenal tumor with heterogeneous intensity. Iodine-131 adosterol scintigraphy showed an increased uptake at the same site. Because feminizing adrenocortical carcinoma was suspected, right adrenalectomy was performed; the pathological diagnosis was adrenocortical carcinoma. The results of immunostaining indicated a virilizing tumor. Aromatase activity was identified on RT-PCR. As disorganized steroidogenesis is pathologically present in adrenocortical carcinoma, this diagnosis should be made with caution. The Japanese Society of Internal Medicine 2016-11-15 /pmc/articles/PMC5173498/ /pubmed/27853073 Text en https://creativecommons.org/licenses/by-nc-nd/4.0/ The Internal Medicine is an Open Access article distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License. To view the details of this license, please visit (https://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Case Report
Hatano, Masako
Takenaka, Yasuhiro
Inoue, Ikuo
Homma, Keiko
Hasegawa, Tomonobu
Sasano, Hisanobu
Awata, Takuya
Katayama, Shigehiro
Feminizing Adrenocortical Carcinoma with Distinct Histopathological Findings
title Feminizing Adrenocortical Carcinoma with Distinct Histopathological Findings
title_full Feminizing Adrenocortical Carcinoma with Distinct Histopathological Findings
title_fullStr Feminizing Adrenocortical Carcinoma with Distinct Histopathological Findings
title_full_unstemmed Feminizing Adrenocortical Carcinoma with Distinct Histopathological Findings
title_short Feminizing Adrenocortical Carcinoma with Distinct Histopathological Findings
title_sort feminizing adrenocortical carcinoma with distinct histopathological findings
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5173498/
https://www.ncbi.nlm.nih.gov/pubmed/27853073
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