Acute Promyelocytic Leukemia with i(17)(q10)

We herein report a rare chromosomal abnormality observed in an acute promyelocytic leukemia (APL) patient. She had several APL derivative clones including a clone with i(17)(q10) abnormality, which consists of two kinds of structural abnormalities, a cryptic translocation of t(15;17) and an isochrom...

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Autores principales: Inamura, Junki, Ikuta, Katsuya, Tsukada, Nodoka, Hosoki, Takaaki, Shindo, Motohiro, Sato, Kazuya
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Japanese Society of Internal Medicine 2016
Materias:
Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5173505/
https://www.ncbi.nlm.nih.gov/pubmed/27853080
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author Inamura, Junki
Ikuta, Katsuya
Tsukada, Nodoka
Hosoki, Takaaki
Shindo, Motohiro
Sato, Kazuya
author_facet Inamura, Junki
Ikuta, Katsuya
Tsukada, Nodoka
Hosoki, Takaaki
Shindo, Motohiro
Sato, Kazuya
author_sort Inamura, Junki
collection PubMed
description We herein report a rare chromosomal abnormality observed in an acute promyelocytic leukemia (APL) patient. She had several APL derivative clones including a clone with i(17)(q10) abnormality, which consists of two kinds of structural abnormalities, a cryptic translocation of t(15;17) and an isochromosome of 17q. Although an obvious microscopic t(15;17) change was not observed on either arms of the isochromosome, PML/RARα fusion signals were detected on an interphase fluorescence in situ hybridization analysis. By several cytogenetic analyses of her bone marrow cells, it was confirmed that the i(17)(q10) clone was derived from the classic t(15;17) clone via another intervening clone, cryptic t(15;17).
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spelling pubmed-51735052016-12-27 Acute Promyelocytic Leukemia with i(17)(q10) Inamura, Junki Ikuta, Katsuya Tsukada, Nodoka Hosoki, Takaaki Shindo, Motohiro Sato, Kazuya Intern Med Case Report We herein report a rare chromosomal abnormality observed in an acute promyelocytic leukemia (APL) patient. She had several APL derivative clones including a clone with i(17)(q10) abnormality, which consists of two kinds of structural abnormalities, a cryptic translocation of t(15;17) and an isochromosome of 17q. Although an obvious microscopic t(15;17) change was not observed on either arms of the isochromosome, PML/RARα fusion signals were detected on an interphase fluorescence in situ hybridization analysis. By several cytogenetic analyses of her bone marrow cells, it was confirmed that the i(17)(q10) clone was derived from the classic t(15;17) clone via another intervening clone, cryptic t(15;17). The Japanese Society of Internal Medicine 2016-11-15 /pmc/articles/PMC5173505/ /pubmed/27853080 Text en https://creativecommons.org/licenses/by-nc-nd/4.0/ The Internal Medicine is an Open Access article distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License. To view the details of this license, please visit (https://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Case Report
Inamura, Junki
Ikuta, Katsuya
Tsukada, Nodoka
Hosoki, Takaaki
Shindo, Motohiro
Sato, Kazuya
Acute Promyelocytic Leukemia with i(17)(q10)
title Acute Promyelocytic Leukemia with i(17)(q10)
title_full Acute Promyelocytic Leukemia with i(17)(q10)
title_fullStr Acute Promyelocytic Leukemia with i(17)(q10)
title_full_unstemmed Acute Promyelocytic Leukemia with i(17)(q10)
title_short Acute Promyelocytic Leukemia with i(17)(q10)
title_sort acute promyelocytic leukemia with i(17)(q10)
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5173505/
https://www.ncbi.nlm.nih.gov/pubmed/27853080
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