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Steroid Pulse Therapy May Mitigate Prolonged Neurological Manifestations after Eradication of Severe Plasmodium falciparum Parasitemia

A 58-year-old Japanese man with a high parasitemia of Plasmodium falciparum, returning from Uganda, was admitted to our hospital since his consciousness level rapidly deteriorated after the initial dose of mefloquine. Despite the parasitemia was cleared by quinine by day 7, the coma remained unchang...

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Detalles Bibliográficos
Autores principales: Hasegawa, Chihiro, Inagaki, Akiko, Yamada, Gohei, Morita, Koji, Kitamura, Isamu, Ariyoshi, Koya
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Japanese Society of Internal Medicine 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5173515/
https://www.ncbi.nlm.nih.gov/pubmed/27853090
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author Hasegawa, Chihiro
Inagaki, Akiko
Yamada, Gohei
Morita, Koji
Kitamura, Isamu
Ariyoshi, Koya
author_facet Hasegawa, Chihiro
Inagaki, Akiko
Yamada, Gohei
Morita, Koji
Kitamura, Isamu
Ariyoshi, Koya
author_sort Hasegawa, Chihiro
collection PubMed
description A 58-year-old Japanese man with a high parasitemia of Plasmodium falciparum, returning from Uganda, was admitted to our hospital since his consciousness level rapidly deteriorated after the initial dose of mefloquine. Despite the parasitemia was cleared by quinine by day 7, the coma remained unchanged and diffuse leukoencephalopathy was detected on magnetic resonance image. Steroid pulse therapy was initiated on day 8. Subsequently, the neurological manifestations improved and he was discharged on day 73 without any sequelae. Pathogenesis of P. falciparum causing cerebral malaria is diverse and complex. If neurological symptoms unusually prolong, steroid may be an effective treatment option.
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spelling pubmed-51735152016-12-27 Steroid Pulse Therapy May Mitigate Prolonged Neurological Manifestations after Eradication of Severe Plasmodium falciparum Parasitemia Hasegawa, Chihiro Inagaki, Akiko Yamada, Gohei Morita, Koji Kitamura, Isamu Ariyoshi, Koya Intern Med Case Report A 58-year-old Japanese man with a high parasitemia of Plasmodium falciparum, returning from Uganda, was admitted to our hospital since his consciousness level rapidly deteriorated after the initial dose of mefloquine. Despite the parasitemia was cleared by quinine by day 7, the coma remained unchanged and diffuse leukoencephalopathy was detected on magnetic resonance image. Steroid pulse therapy was initiated on day 8. Subsequently, the neurological manifestations improved and he was discharged on day 73 without any sequelae. Pathogenesis of P. falciparum causing cerebral malaria is diverse and complex. If neurological symptoms unusually prolong, steroid may be an effective treatment option. The Japanese Society of Internal Medicine 2016-11-15 /pmc/articles/PMC5173515/ /pubmed/27853090 Text en https://creativecommons.org/licenses/by-nc-nd/4.0/ The Internal Medicine is an Open Access article distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License. To view the details of this license, please visit (https://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Case Report
Hasegawa, Chihiro
Inagaki, Akiko
Yamada, Gohei
Morita, Koji
Kitamura, Isamu
Ariyoshi, Koya
Steroid Pulse Therapy May Mitigate Prolonged Neurological Manifestations after Eradication of Severe Plasmodium falciparum Parasitemia
title Steroid Pulse Therapy May Mitigate Prolonged Neurological Manifestations after Eradication of Severe Plasmodium falciparum Parasitemia
title_full Steroid Pulse Therapy May Mitigate Prolonged Neurological Manifestations after Eradication of Severe Plasmodium falciparum Parasitemia
title_fullStr Steroid Pulse Therapy May Mitigate Prolonged Neurological Manifestations after Eradication of Severe Plasmodium falciparum Parasitemia
title_full_unstemmed Steroid Pulse Therapy May Mitigate Prolonged Neurological Manifestations after Eradication of Severe Plasmodium falciparum Parasitemia
title_short Steroid Pulse Therapy May Mitigate Prolonged Neurological Manifestations after Eradication of Severe Plasmodium falciparum Parasitemia
title_sort steroid pulse therapy may mitigate prolonged neurological manifestations after eradication of severe plasmodium falciparum parasitemia
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5173515/
https://www.ncbi.nlm.nih.gov/pubmed/27853090
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