Diurnal difference in CAR mRNA expression

BACKGROUND: The constitutive androstane receptor (CAR, NR1I3) plays a key role in the transcriptional activation of genes that encode xenobiotic/steroid and drug metabolizing enzymes. RESULTS: The expression of CAR mRNA throughout the circadian rhythm is reported for the first time in phase with the...

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Autores principales: Kanno, Yuichiro, Otsuka, Satoshi, Hiromasa, Takuya, Nakahama, Takayuki, Inouye, Yoshio
Formato: Texto
Lenguaje:English
Publicado: BioMed Central 2004
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC517509/
https://www.ncbi.nlm.nih.gov/pubmed/15333129
http://dx.doi.org/10.1186/1478-1336-2-6
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author Kanno, Yuichiro
Otsuka, Satoshi
Hiromasa, Takuya
Nakahama, Takayuki
Inouye, Yoshio
author_facet Kanno, Yuichiro
Otsuka, Satoshi
Hiromasa, Takuya
Nakahama, Takayuki
Inouye, Yoshio
author_sort Kanno, Yuichiro
collection PubMed
description BACKGROUND: The constitutive androstane receptor (CAR, NR1I3) plays a key role in the transcriptional activation of genes that encode xenobiotic/steroid and drug metabolizing enzymes. RESULTS: The expression of CAR mRNA throughout the circadian rhythm is reported for the first time in phase with the clock gene Bmal1 and in antiphase with the clock-controlled gene Rev-erbα mRNAs, with a peak at Zeitgeber time (ZT) 20 and a trough at ZT8, and a peak/trough ratio of 2.0. The diurnal difference in CAR mRNA expression might underlie the 1.7-fold difference in the magnitude of the PB-dependent induction of CYP2B1/2 mRNA. CONCLUSION: The circadian oscillation of xenosensor gene CAR mRNA expression is partially responsible for chronopharmacokinetics and chronopharmacology in disease.
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spelling pubmed-5175092004-09-17 Diurnal difference in CAR mRNA expression Kanno, Yuichiro Otsuka, Satoshi Hiromasa, Takuya Nakahama, Takayuki Inouye, Yoshio Nucl Recept Research BACKGROUND: The constitutive androstane receptor (CAR, NR1I3) plays a key role in the transcriptional activation of genes that encode xenobiotic/steroid and drug metabolizing enzymes. RESULTS: The expression of CAR mRNA throughout the circadian rhythm is reported for the first time in phase with the clock gene Bmal1 and in antiphase with the clock-controlled gene Rev-erbα mRNAs, with a peak at Zeitgeber time (ZT) 20 and a trough at ZT8, and a peak/trough ratio of 2.0. The diurnal difference in CAR mRNA expression might underlie the 1.7-fold difference in the magnitude of the PB-dependent induction of CYP2B1/2 mRNA. CONCLUSION: The circadian oscillation of xenosensor gene CAR mRNA expression is partially responsible for chronopharmacokinetics and chronopharmacology in disease. BioMed Central 2004-08-28 /pmc/articles/PMC517509/ /pubmed/15333129 http://dx.doi.org/10.1186/1478-1336-2-6 Text en Copyright © 2004 Kanno et al; licensee BioMed Central Ltd. http://creativecommons.org/licenses/by/2.0 This is an open-access article distributed under the terms of the Creative Commons Attribution License ( (http://creativecommons.org/licenses/by/2.0) ), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research
Kanno, Yuichiro
Otsuka, Satoshi
Hiromasa, Takuya
Nakahama, Takayuki
Inouye, Yoshio
Diurnal difference in CAR mRNA expression
title Diurnal difference in CAR mRNA expression
title_full Diurnal difference in CAR mRNA expression
title_fullStr Diurnal difference in CAR mRNA expression
title_full_unstemmed Diurnal difference in CAR mRNA expression
title_short Diurnal difference in CAR mRNA expression
title_sort diurnal difference in car mrna expression
topic Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC517509/
https://www.ncbi.nlm.nih.gov/pubmed/15333129
http://dx.doi.org/10.1186/1478-1336-2-6
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AT otsukasatoshi diurnaldifferenceincarmrnaexpression
AT hiromasatakuya diurnaldifferenceincarmrnaexpression
AT nakahamatakayuki diurnaldifferenceincarmrnaexpression
AT inouyeyoshio diurnaldifferenceincarmrnaexpression

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