Structural basis of the substrate preference towards CMP for a thymidylate synthase MilA involved in mildiomycin biosynthesis

Modified pyrimidine monophosphates such as methyl dCMP (mdCMP), hydroxymethyl dUMP (hmdUMP) and hmdCMP in some phages are synthesized by a large group of enzymes termed as thymidylate synthases (TS). Thymidylate is a nucleotide required for DNA synthesis and thus TS is an important drug target. In t...

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Detalles Bibliográficos
Autores principales: Zhao, Gong, Chen, Cheng, Xiong, Wei, Gao, Tuling, Deng, Zixin, Wu, Geng, He, Xinyi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5175136/
https://www.ncbi.nlm.nih.gov/pubmed/28000775
http://dx.doi.org/10.1038/srep39675

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5175136/
https://www.ncbi.nlm.nih.gov/pubmed/28000775
http://dx.doi.org/10.1038/srep39675

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