An acridine derivative, [4,5-bis{(N-carboxy methyl imidazolium)methyl}acridine] dibromide, shows anti-TDP-43 aggregation effect in ALS disease models

Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disease associated with aggregation of TAR DNA-binding protein-43 (TDP-43) in neuronal cells and manifests as motor neuron dysfunction & muscle atrophy. The carboxyl-terminal prion-like domain of TDP-43 can aggregate in vitro into...

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Detalles Bibliográficos
Autores principales: Prasad, Archana, Raju, Gembali, Sivalingam, Vishwanath, Girdhar, Amandeep, Verma, Meenakshi, Vats, Abhishek, Taneja, Vibha, Prabusankar, Ganesan, Patel, Basant K.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5175139/
https://www.ncbi.nlm.nih.gov/pubmed/28000730
http://dx.doi.org/10.1038/srep39490

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