β-subunit myristoylation functions as an energy sensor by modulating the dynamics of AMP-activated Protein Kinase

The heterotrimeric AMP-activated protein kinase (AMPK), consisting of α, β and γ subunits, is a stress-sensing enzyme that is activated by phosphorylation of its activation loop in response to increases in cellular AMP. N-terminal myristoylation of the β-subunit has been shown to suppress Thr172 pho...

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Detalles Bibliográficos
Autores principales: Ali, Nada, Ling, Naomi, Krishnamurthy, Srinath, Oakhill, Jonathan S., Scott, John W., Stapleton, David I., Kemp, Bruce E., Anand, Ganesh Srinivasan, Gooley, Paul R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5175161/
https://www.ncbi.nlm.nih.gov/pubmed/28000716
http://dx.doi.org/10.1038/srep39417

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