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Serum Klotho (but not haplotypes) associate with the post-myocardial infarction status of older adults
OBJECTIVES: The number of deaths from vascular diseases is incredibly high worldwide, and reliable markers for major events are still needed. The current cross-sectional study investigated the association of Klotho haplotypes and Klotho serum levels with classic risk factors and a clinical history o...
Autores principales: | , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo
2016
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5175288/ https://www.ncbi.nlm.nih.gov/pubmed/28076518 http://dx.doi.org/10.6061/clinics/2016(12)09 |
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author | Paula, Roberta S Souza, Vinícius C Machado-Silva, Wilcelly Almeida, Bruno Ratier S Daros, Andersen C Gomes, Lucy Ferreira, Aparecido P Brito, Ciro J Córdova, Cláudio Moraes, Clayton F Nóbrega, Otávio T |
author_facet | Paula, Roberta S Souza, Vinícius C Machado-Silva, Wilcelly Almeida, Bruno Ratier S Daros, Andersen C Gomes, Lucy Ferreira, Aparecido P Brito, Ciro J Córdova, Cláudio Moraes, Clayton F Nóbrega, Otávio T |
author_sort | Paula, Roberta S |
collection | PubMed |
description | OBJECTIVES: The number of deaths from vascular diseases is incredibly high worldwide, and reliable markers for major events are still needed. The current cross-sectional study investigated the association of Klotho haplotypes and Klotho serum levels with classic risk factors and a clinical history of vascular events. METHODS: Clinical, anthropometric, biochemical and nutritional assessments were conducted with 168 older adults, complemented by genotyping (rs9536314 and rs9527025) and the detection of serum Klotho (ELISA). RESULTS: Klotho levels and haplotypes did not associate with most classic risk factors for vascular events, including markers such as C-reactive protein and homocysteine. A positive association was only found between Klotho levels and the previous occurrence of a myocardial infarction by both correlational (p=0.006) and variance analyses (p<0.001), and these associations were independent of the context. CONCLUSION: Our results suggest that serum Klotho is higher in individuals with a clinical history of myocardial infarction but not with a history of coronary artery disease or stroke. None of the Klotho haplotypes were associated with the variables investigated herein. |
format | Online Article Text |
id | pubmed-5175288 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2016 |
publisher | Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo |
record_format | MEDLINE/PubMed |
spelling | pubmed-51752882016-12-23 Serum Klotho (but not haplotypes) associate with the post-myocardial infarction status of older adults Paula, Roberta S Souza, Vinícius C Machado-Silva, Wilcelly Almeida, Bruno Ratier S Daros, Andersen C Gomes, Lucy Ferreira, Aparecido P Brito, Ciro J Córdova, Cláudio Moraes, Clayton F Nóbrega, Otávio T Clinics (Sao Paulo) Clinical Science OBJECTIVES: The number of deaths from vascular diseases is incredibly high worldwide, and reliable markers for major events are still needed. The current cross-sectional study investigated the association of Klotho haplotypes and Klotho serum levels with classic risk factors and a clinical history of vascular events. METHODS: Clinical, anthropometric, biochemical and nutritional assessments were conducted with 168 older adults, complemented by genotyping (rs9536314 and rs9527025) and the detection of serum Klotho (ELISA). RESULTS: Klotho levels and haplotypes did not associate with most classic risk factors for vascular events, including markers such as C-reactive protein and homocysteine. A positive association was only found between Klotho levels and the previous occurrence of a myocardial infarction by both correlational (p=0.006) and variance analyses (p<0.001), and these associations were independent of the context. CONCLUSION: Our results suggest that serum Klotho is higher in individuals with a clinical history of myocardial infarction but not with a history of coronary artery disease or stroke. None of the Klotho haplotypes were associated with the variables investigated herein. Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo 2016-12 2016-12 /pmc/articles/PMC5175288/ /pubmed/28076518 http://dx.doi.org/10.6061/clinics/2016(12)09 Text en Copyright © 2016 CLINICS http://creativecommons.org/licenses/by/4.0/ This is an Open Access article distributed under the terms of the Creative Commons License (http://creativecommons.org/licenses/by/4.0/) which permits unrestricted use, distribution, and reproduction in any medium or format, provided the original work is properly cited. |
spellingShingle | Clinical Science Paula, Roberta S Souza, Vinícius C Machado-Silva, Wilcelly Almeida, Bruno Ratier S Daros, Andersen C Gomes, Lucy Ferreira, Aparecido P Brito, Ciro J Córdova, Cláudio Moraes, Clayton F Nóbrega, Otávio T Serum Klotho (but not haplotypes) associate with the post-myocardial infarction status of older adults |
title | Serum Klotho (but not haplotypes) associate with the post-myocardial infarction status of older adults |
title_full | Serum Klotho (but not haplotypes) associate with the post-myocardial infarction status of older adults |
title_fullStr | Serum Klotho (but not haplotypes) associate with the post-myocardial infarction status of older adults |
title_full_unstemmed | Serum Klotho (but not haplotypes) associate with the post-myocardial infarction status of older adults |
title_short | Serum Klotho (but not haplotypes) associate with the post-myocardial infarction status of older adults |
title_sort | serum klotho (but not haplotypes) associate with the post-myocardial infarction status of older adults |
topic | Clinical Science |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5175288/ https://www.ncbi.nlm.nih.gov/pubmed/28076518 http://dx.doi.org/10.6061/clinics/2016(12)09 |
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