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Tunable regulation of CREB DNA binding activity couples genotoxic stress response and metabolism

cAMP response element binding protein (CREB) is a key regulator of glucose metabolism and synaptic plasticity that is canonically regulated through recruitment of transcriptional coactivators. Here we show that phosphorylation of CREB on a conserved cluster of Ser residues (the ATM/CK cluster) by th...

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Detalles Bibliográficos
Autores principales:	Kim, Sang Hwa, Trinh, Anthony T., Larsen, Michele Campaigne, Mastrocola, Adam S., Jefcoate, Colin R., Bushel, Pierre R., Tibbetts, Randal S.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Oxford University Press 2016
Materias:	Gene regulation, Chromatin and Epigenetics
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5175338/ https://www.ncbi.nlm.nih.gov/pubmed/27431323 http://dx.doi.org/10.1093/nar/gkw643

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