H2B ubiquitination regulates meiotic recombination by promoting chromatin relaxation

Meiotic recombination is essential for fertility in most sexually reproducing species, but the molecular mechanisms underlying this process remain poorly understood in mammals. Here, we show that RNF20-mediated H2B ubiquitination is required for meiotic recombination. A germ cell-specific knockout o...

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Detalles Bibliográficos
Autores principales: Xu, Zhiliang, Song, Zhenhua, Li, Guoping, Tu, Huayu, Liu, Weixiao, Liu, Yujiao, Wang, Pan, Wang, Yuanting, Cui, Xiuhong, Liu, Chao, Shang, Yongliang, de Rooij, Dirk G., Gao, Fei, Li, Wei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2016
Materias:
Gene regulation, Chromatin and Epigenetics
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5175339/
https://www.ncbi.nlm.nih.gov/pubmed/27431324
http://dx.doi.org/10.1093/nar/gkw652

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