Cargando…

eIF2β is critical for eIF5-mediated GDP-dissociation inhibitor activity and translational control

In protein synthesis translation factor eIF2 binds initiator tRNA to ribosomes and facilitates start codon selection. eIF2 GDP/GTP status is regulated by eIF5 (GAP and GDI functions) and eIF2B (GEF and GDF activities), while eIF2α phosphorylation in response to diverse signals is a major point of tr...

Descripción completa

Detalles Bibliográficos
Autores principales:	Jennings, Martin D., Kershaw, Christopher J., White, Christopher, Hoyle, Danielle, Richardson, Jonathan P., Costello, Joseph L., Donaldson, Ian J., Zhou, Yu, Pavitt, Graham D.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Oxford University Press 2016
Materias:	Gene regulation, Chromatin and Epigenetics
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5175340/ https://www.ncbi.nlm.nih.gov/pubmed/27458202 http://dx.doi.org/10.1093/nar/gkw657

Ejemplares similares

Mechanisms of translational regulation by a human eIF5-mimic protein
por: Singh, Chingakham Ranjit, et al.
Publicado: (2011)

An interaction between eIF4A3 and eIF3g drives the internal initiation of translation
por: Chang, Jeeyoon, et al.
Publicado: (2023)

Identifying eIF4E-binding protein translationally-controlled transcripts reveals links to mRNAs bound by specific PUF proteins
por: Cridge, Andrew G., et al.
Publicado: (2010)

eIF2B promotes eIF5 dissociation from eIF2•GDP to facilitate guanine nucleotide exchange for translation initiation
por: Jennings, Martin D., et al.
Publicado: (2013)

Differential regulation of CHOP translation by phosphorylated eIF4E under stress conditions
por: Chen, Yi-Jiun, et al.
Publicado: (2010)

Overexpression of eIF5 or its protein mimic 5MP perturbs eIF2 function and induces ATF4 translation through delayed re-initiation
por: Kozel, Caitlin, et al.
Publicado: (2016)

Translation reprogramming by eIF3 linked to glioblastoma resistance
por: Bertorello, Juliette, et al.
Publicado: (2020)

Stringency of start codon selection modulates autoregulation of translation initiation factor eIF5
por: Loughran, Gary, et al.
Publicado: (2012)

eIF3j inhibits translation of a subset of circular RNAs in eukaryotic cells
por: Song, Zhenxing, et al.
Publicado: (2022)

Large-scale movement of eIF3 domains during translation initiation modulate start codon selection
por: Llácer, Jose L, et al.
Publicado: (2021)

IRES-mediated translation of cellular messenger RNA operates in eIF2α- independent manner during stress
por: Thakor, Nehal, et al.
Publicado: (2012)

The eIF2α/ATF4 pathway is essential for stress-induced autophagy gene expression
por: B’chir, Wafa, et al.
Publicado: (2013)

The eIF3 complex of Leishmania—subunit composition and mode of recruitment to different cap-binding complexes
por: Meleppattu, Shimi, et al.
Publicado: (2015)

40S recruitment in the absence of eIF4G/4A by EMCV IRES refines the model for translation initiation on the archetype of Type II IRESs
por: Chamond, Nathalie, et al.
Publicado: (2014)

Gcn2 eIF2α kinase mediates combinatorial translational regulation through nucleotide motifs and uORFs in target mRNAs
por: Chikashige, Yuji, et al.
Publicado: (2020)

Essential role of eIF5-mimic protein in animal development is linked to control of ATF4 expression
por: Hiraishi, Hiroyuki, et al.
Publicado: (2014)

Eukaryotic translation initiation factor eIF5 promotes the accuracy of start codon recognition by regulating P(i) release and conformational transitions of the preinitiation complex
por: Saini, Adesh K., et al.
Publicado: (2014)

Fail-safe control of translation initiation by dissociation of eIF2α phosphorylated ternary complexes
por: Jennings, Martin D, et al.
Publicado: (2017)

PERK/eIF2α signaling inhibits HIF-induced gene expression during the unfolded protein response via YB1-dependent regulation of HIF1α translation
por: Ivanova, Iglika G, et al.
Publicado: (2018)

Identification and characterization of hippuristanol-resistant mutants reveals eIF4A1 dependencies within mRNA 5′ leader regions
por: Steinberger, Jutta, et al.
Publicado: (2020)

Eukaryotic initiation factor (eIF) 3 mediates Barley Yellow Dwarf Viral mRNA 3′–5′ UTR interactions and 40S ribosomal subunit binding to facilitate cap-independent translation
por: Bhardwaj, Usha, et al.
Publicado: (2019)

eIF5 has GDI activity necessary for translational control by eIF2 phosphorylation
por: Jennings, Martin D., et al.
Publicado: (2010)

Structure of the Tandem MA-3 Region of Pdcd4 Protein and Characterization of Its Interactions with eIF4A and eIF4G: MOLECULAR MECHANISMS OF A TUMOR SUPPRESSOR
por: Waters, Lorna C., et al.
Publicado: (2011)

A novel 4E-interacting protein in Leishmania is involved in stage-specific translation pathways
por: Zinoviev, Alexandra, et al.
Publicado: (2011)

GTP binding to translation factor eIF2B stimulates its guanine nucleotide exchange activity
por: Kershaw, Christopher J., et al.
Publicado: (2021)

Distinct interactions of eIF4A and eIF4E with RNA helicase Ded1 stimulate translation in vivo
por: Gulay, Suna, et al.
Publicado: (2020)

The structural basis of translational control by eIF2 phosphorylation
por: Adomavicius, Tomas, et al.
Publicado: (2019)

Predicting the strength of UP-elements and full-length E. coli σ(E) promoters
por: Rhodius, Virgil A., et al.
Publicado: (2012)

Quantitative models for accelerated protein dissociation from nucleosomal DNA
por: Chen, Cai, et al.
Publicado: (2014)

Methylation of human eukaryotic elongation factor alpha (eEF1A) by a member of a novel protein lysine methyltransferase family modulates mRNA translation
por: Jakobsson, Magnus E., et al.
Publicado: (2017)

The 4E-BP Caf20p Mediates Both eIF4E-Dependent and Independent Repression of Translation
por: Castelli, Lydia M., et al.
Publicado: (2015)

Early fate of exogenous promoters in E. coli
por: Yousuf, Malikmohamed, et al.
Publicado: (2020)

Conformational changes and catalytic inefficiency associated with Mot1-mediated TBP–DNA dissociation
por: Heiss, Gregor, et al.
Publicado: (2019)

The transcription factor network of E. coli steers global responses to shifts in RNAP concentration
por: L.B. Almeida, Bilena, et al.
Publicado: (2022)

Repressor CopG prevents access of RNA polymerase to promoter and actively dissociates open complexes
por: Hernández-Arriaga, Ana M., et al.
Publicado: (2009)

Sudemycin E influences alternative splicing and changes chromatin modifications
por: Convertini, Paolo, et al.
Publicado: (2014)

The novel lysine specific methyltransferase METTL21B affects mRNA translation through inducible and dynamic methylation of Lys-165 in human eukaryotic elongation factor 1 alpha (eEF1A)
por: Małecki, Jędrzej, et al.
Publicado: (2017)

The conserved regulatory RNA RsaE down-regulates the arginine degradation pathway in Staphylococcus aureus
por: Rochat, Tatiana, et al.
Publicado: (2018)

Alteration of DNA supercoiling serves as a trigger of short-term cold shock repressed genes of E. coli
por: Dash, Suchintak, et al.
Publicado: (2022)

Differential involvement of E2A-corepressor interactions in distinct leukemogenic pathways
por: Gow, Chien-Hung, et al.
Publicado: (2014)

Cannot write session to /tmp/vufind_sessions/sess_h1ojkmnlbr1a3tobctppm3mtmd