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The C/ebp-Atf response element (CARE) location reveals two distinct Atf4-dependent, elongation-mediated mechanisms for transcriptional induction of aminoacyl-tRNA synthetase genes in response to amino acid limitation

The response to amino acid (AA) limitation of the entire aminoacyl-tRNA synthetase (ARS) gene family revealed that 16/20 of the genes encoding cytoplasmic-localized enzymes are transcriptionally induced by activating transcription factor 4 (Atf4) via C/ebp-Atf-Response-Element (CARE) enhancers. In c...

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Detalles Bibliográficos
Autores principales:	Shan, Jixiu, Zhang, Fan, Sharkey, Jason, Tang, Tiffany A., Örd, Tönis, Kilberg, Michael S.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Oxford University Press 2016
Materias:	Gene regulation, Chromatin and Epigenetics
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5175342/ https://www.ncbi.nlm.nih.gov/pubmed/27471030 http://dx.doi.org/10.1093/nar/gkw667

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