Chtop (Chromatin target of Prmt1) auto-regulates its expression level via intron retention and nonsense-mediated decay of its own mRNA

Chtop (chromatin target of Prmt1) regulates various aspects of gene expression including transcription and mRNA export. Despite these important functions, the regulatory mechanism underlying Chtop expression remains undetermined. Using Chtop-expressing human cell lines, we demonstrate that Chtop exp...

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Detalles Bibliográficos
Autores principales: Izumikawa, Keiichi, Yoshikawa, Harunori, Ishikawa, Hideaki, Nobe, Yuko, Yamauchi, Yoshio, Philipsen, Sjaak, Simpson, Richard J, Isobe, Toshiaki, Takahashi, Nobuhiro
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2016
Materias:
Molecular Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5175361/
https://www.ncbi.nlm.nih.gov/pubmed/27683223
http://dx.doi.org/10.1093/nar/gkw831

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