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Laboratory evolution of artificially expanded DNA gives redesignable aptamers that target the toxic form of anthrax protective antigen

Reported here is a laboratory in vitro evolution (LIVE) experiment based on an artificially expanded genetic information system (AEGIS). This experiment delivers the first example of an AEGIS aptamer that binds to an isolated protein target, the first whose structural contact with its target has bee...

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Detalles Bibliográficos
Autores principales:	Biondi, Elisa, Lane, Joshua D., Das, Debasis, Dasgupta, Saurja, Piccirilli, Joseph A., Hoshika, Shuichi, Bradley, Kevin M., Krantz, Bryan A., Benner, Steven A.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Oxford University Press 2016
Materias:	Chemical Biology and Nucleic Acid Chemistry
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5175368/ https://www.ncbi.nlm.nih.gov/pubmed/27701076 http://dx.doi.org/10.1093/nar/gkw890

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