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Mammalian sperm nuclear organization: resiliencies and vulnerabilities
Sperm cells are remarkably complex and highly specialized compared to somatic cells. Their function is to deliver to the oocyte the paternal genomic blueprint along with a pool of proteins and RNAs so a new generation can begin. Reproductive success, including optimal embryonic development and healt...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2016
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5175393/ https://www.ncbi.nlm.nih.gov/pubmed/28031843 http://dx.doi.org/10.1186/s12610-016-0044-5 |
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author | Champroux, A. Torres-Carreira, J. Gharagozloo, P. Drevet, J. R. Kocer, A. |
author_facet | Champroux, A. Torres-Carreira, J. Gharagozloo, P. Drevet, J. R. Kocer, A. |
author_sort | Champroux, A. |
collection | PubMed |
description | Sperm cells are remarkably complex and highly specialized compared to somatic cells. Their function is to deliver to the oocyte the paternal genomic blueprint along with a pool of proteins and RNAs so a new generation can begin. Reproductive success, including optimal embryonic development and healthy offspring, greatly depends on the integrity of the sperm chromatin structure. It is now well documented that DNA damage in sperm is linked to reproductive failures both in natural and assisted conception (Assisted Reproductive Technologies [ART]). This manuscript reviews recent important findings concerning - the unusual organization of mammalian sperm chromatin and its impact on reproductive success when modified. This review is focused on sperm chromatin damage and their impact on embryonic development and transgenerational inheritance. |
format | Online Article Text |
id | pubmed-5175393 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2016 |
publisher | BioMed Central |
record_format | MEDLINE/PubMed |
spelling | pubmed-51753932016-12-28 Mammalian sperm nuclear organization: resiliencies and vulnerabilities Champroux, A. Torres-Carreira, J. Gharagozloo, P. Drevet, J. R. Kocer, A. Basic Clin Androl Review Article Sperm cells are remarkably complex and highly specialized compared to somatic cells. Their function is to deliver to the oocyte the paternal genomic blueprint along with a pool of proteins and RNAs so a new generation can begin. Reproductive success, including optimal embryonic development and healthy offspring, greatly depends on the integrity of the sperm chromatin structure. It is now well documented that DNA damage in sperm is linked to reproductive failures both in natural and assisted conception (Assisted Reproductive Technologies [ART]). This manuscript reviews recent important findings concerning - the unusual organization of mammalian sperm chromatin and its impact on reproductive success when modified. This review is focused on sperm chromatin damage and their impact on embryonic development and transgenerational inheritance. BioMed Central 2016-12-21 /pmc/articles/PMC5175393/ /pubmed/28031843 http://dx.doi.org/10.1186/s12610-016-0044-5 Text en © The Author(s). 2016 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated. |
spellingShingle | Review Article Champroux, A. Torres-Carreira, J. Gharagozloo, P. Drevet, J. R. Kocer, A. Mammalian sperm nuclear organization: resiliencies and vulnerabilities |
title | Mammalian sperm nuclear organization: resiliencies and vulnerabilities |
title_full | Mammalian sperm nuclear organization: resiliencies and vulnerabilities |
title_fullStr | Mammalian sperm nuclear organization: resiliencies and vulnerabilities |
title_full_unstemmed | Mammalian sperm nuclear organization: resiliencies and vulnerabilities |
title_short | Mammalian sperm nuclear organization: resiliencies and vulnerabilities |
title_sort | mammalian sperm nuclear organization: resiliencies and vulnerabilities |
topic | Review Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5175393/ https://www.ncbi.nlm.nih.gov/pubmed/28031843 http://dx.doi.org/10.1186/s12610-016-0044-5 |
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