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Indexes of Insulin Resistance in Hyperinsulinemic Polycystic Ovary Syndrome in a Macedonian Cohort of Women of Reproductive Age: A Cross-Sectional Study
BACKGROUND: Polycystic ovary syndrome (PCOS) is complex hormonal, metabolic and reproductive disorder and is a leading cause of female infertility. Hyperinsulinemia secondary to insulin resistance plays important role in the pathogenesis of PCOS. AIM: To assess the sensitivity of different indices o...
Autores principales: | , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Institute of Immunobiology and Human Genetics
2016
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5175507/ https://www.ncbi.nlm.nih.gov/pubmed/28028399 http://dx.doi.org/10.3889/oamjms.2016.107 |
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author | Jovanovska-Mishevska, Sasha Atanasova-Boshku, Aleksandra Bitoska, Iskra Ahmeti, Irfan Todorova, Biljana Pemovska, Gordana Milenkovic, Tatjana Krstevska, Brankica |
author_facet | Jovanovska-Mishevska, Sasha Atanasova-Boshku, Aleksandra Bitoska, Iskra Ahmeti, Irfan Todorova, Biljana Pemovska, Gordana Milenkovic, Tatjana Krstevska, Brankica |
author_sort | Jovanovska-Mishevska, Sasha |
collection | PubMed |
description | BACKGROUND: Polycystic ovary syndrome (PCOS) is complex hormonal, metabolic and reproductive disorder and is a leading cause of female infertility. Hyperinsulinemia secondary to insulin resistance plays important role in the pathogenesis of PCOS. AIM: To assess the sensitivity of different indices of insulin resistance and their relevance in a clinical setting. MATERIAL AND METHODS: A cross-sectional study of 43 patients with PCOS and 29 noromo ovulatory women as a control group was conducted. Standard clinical, anthropometrical and hormonal testing for hyperandrogenism was conducted, as well as oral glucose tolerance test with determination of basal and stimulated glucose and insulin values. RESULTS: The dynamic I/G index showed the highest sensitivity and specificity, but the static indexes HOMA-IR and QUICKI, although based on only basal glycemic and insulinemic values, showed good sensitivity, 90.38% and 94.01% respectively. HOMA-IR showed significant positive correlation with the stimulated insulin values. CONCLUSIONS: Our results support the use of static indexes in the evaluation of insulin resistance in women with PCOS in a clinical setting, offering a simple assessment of insulin resistance in PCOS, which holds great prognostic and treatment implications. |
format | Online Article Text |
id | pubmed-5175507 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2016 |
publisher | Institute of Immunobiology and Human Genetics |
record_format | MEDLINE/PubMed |
spelling | pubmed-51755072016-12-27 Indexes of Insulin Resistance in Hyperinsulinemic Polycystic Ovary Syndrome in a Macedonian Cohort of Women of Reproductive Age: A Cross-Sectional Study Jovanovska-Mishevska, Sasha Atanasova-Boshku, Aleksandra Bitoska, Iskra Ahmeti, Irfan Todorova, Biljana Pemovska, Gordana Milenkovic, Tatjana Krstevska, Brankica Open Access Maced J Med Sci Clinical Science BACKGROUND: Polycystic ovary syndrome (PCOS) is complex hormonal, metabolic and reproductive disorder and is a leading cause of female infertility. Hyperinsulinemia secondary to insulin resistance plays important role in the pathogenesis of PCOS. AIM: To assess the sensitivity of different indices of insulin resistance and their relevance in a clinical setting. MATERIAL AND METHODS: A cross-sectional study of 43 patients with PCOS and 29 noromo ovulatory women as a control group was conducted. Standard clinical, anthropometrical and hormonal testing for hyperandrogenism was conducted, as well as oral glucose tolerance test with determination of basal and stimulated glucose and insulin values. RESULTS: The dynamic I/G index showed the highest sensitivity and specificity, but the static indexes HOMA-IR and QUICKI, although based on only basal glycemic and insulinemic values, showed good sensitivity, 90.38% and 94.01% respectively. HOMA-IR showed significant positive correlation with the stimulated insulin values. CONCLUSIONS: Our results support the use of static indexes in the evaluation of insulin resistance in women with PCOS in a clinical setting, offering a simple assessment of insulin resistance in PCOS, which holds great prognostic and treatment implications. Institute of Immunobiology and Human Genetics 2016-12-15 2016-09-26 /pmc/articles/PMC5175507/ /pubmed/28028399 http://dx.doi.org/10.3889/oamjms.2016.107 Text en Copyright: © 2016 Sasha Jovanovska-Mishevska, Aleksandra Atanasova-Boshku, Iskra Bitoska, Irfan Ahmeti, Biljana Todorova, Gordana Pemovska, Tatjana Milenkovic, Brankica Krstevska. http://creativecommons.org/licenses/CC BY-NC/4.0 This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International License (CC BY-NC 4.0). |
spellingShingle | Clinical Science Jovanovska-Mishevska, Sasha Atanasova-Boshku, Aleksandra Bitoska, Iskra Ahmeti, Irfan Todorova, Biljana Pemovska, Gordana Milenkovic, Tatjana Krstevska, Brankica Indexes of Insulin Resistance in Hyperinsulinemic Polycystic Ovary Syndrome in a Macedonian Cohort of Women of Reproductive Age: A Cross-Sectional Study |
title | Indexes of Insulin Resistance in Hyperinsulinemic Polycystic Ovary Syndrome in a Macedonian Cohort of Women of Reproductive Age: A Cross-Sectional Study |
title_full | Indexes of Insulin Resistance in Hyperinsulinemic Polycystic Ovary Syndrome in a Macedonian Cohort of Women of Reproductive Age: A Cross-Sectional Study |
title_fullStr | Indexes of Insulin Resistance in Hyperinsulinemic Polycystic Ovary Syndrome in a Macedonian Cohort of Women of Reproductive Age: A Cross-Sectional Study |
title_full_unstemmed | Indexes of Insulin Resistance in Hyperinsulinemic Polycystic Ovary Syndrome in a Macedonian Cohort of Women of Reproductive Age: A Cross-Sectional Study |
title_short | Indexes of Insulin Resistance in Hyperinsulinemic Polycystic Ovary Syndrome in a Macedonian Cohort of Women of Reproductive Age: A Cross-Sectional Study |
title_sort | indexes of insulin resistance in hyperinsulinemic polycystic ovary syndrome in a macedonian cohort of women of reproductive age: a cross-sectional study |
topic | Clinical Science |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5175507/ https://www.ncbi.nlm.nih.gov/pubmed/28028399 http://dx.doi.org/10.3889/oamjms.2016.107 |
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