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Emphysema and Airflow Obstruction in Non-Smoking Coal Miners with Pneumoconiosis
BACKGROUND: Accumulating evidence shows that functional impairment in subjects with coal workers’ pneumoconiosis (CWP) is principally due to emphysema and airflow obstruction, rather than underlying restrictive mechanisms. However, cigarette smoking has remained a major confounder. The aim of this s...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
International Scientific Literature, Inc.
2016
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5175685/ https://www.ncbi.nlm.nih.gov/pubmed/27956734 http://dx.doi.org/10.12659/MSM.901820 |
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author | Altınsoy, Bülent Öz, İbrahim İlker Erboy, Fatma Tor, Meltem Atalay, Figen |
author_facet | Altınsoy, Bülent Öz, İbrahim İlker Erboy, Fatma Tor, Meltem Atalay, Figen |
author_sort | Altınsoy, Bülent |
collection | PubMed |
description | BACKGROUND: Accumulating evidence shows that functional impairment in subjects with coal workers’ pneumoconiosis (CWP) is principally due to emphysema and airflow obstruction, rather than underlying restrictive mechanisms. However, cigarette smoking has remained a major confounder. The aim of this study was to assess whether coal dust exposure was associated with emphysema and/or airflow obstruction in the absence of smoking history. MATERIAL/METHOD: The subjects evaluated for possible pneumoconiosis between 2013 and 2015 were retrospectively enrolled into this study. After excluding those with history of smoking, tuberculosis, or lung cancer, the study population was a total of 57 subjects. The emphysema severity and airflow obstruction were quantified by computed tomographic densitometry analysis and spirometry, respectively. For comparability regarding emphysema, 9 age- and sex-matched nonsmoker (n=9) control subjects without known lung disease were randomly selected from a radiology database. RESULTS: Emphysema severity was significantly higher in the CWP group compared with the control group (15% vs. 4%, p<0.001). The median percent emphysema and percentage of those with FEV1/FVC <0.7 was 13% and 37% in subjects with simple CWP and 18% and 67% in subjects with complicated CWP, respectively. Percent emphysema and Perc15 (15(th) percentile of the attenuation curve) was correlated with FEV1/FVC (r=−0.45, r=−0.47) and FEF25–75 (r=−0.36, r=−0.56), respectively, but not with perfusion score. A linear regression analysis showed that factors associated with emphysema were FEV1/FVC (β=−0.24, p=0.009) and large opacity (β=−3.97, p=0.079), and factors associated with FEV1/FVC were percent emphysema (β=−0.51, p=0.018) and tenure (β=−0.63, p=0.044). CONCLUSIONS: Our results support the observation that coal dust exposure is associated with emphysema and airflow obstruction, independent of smoking status. |
format | Online Article Text |
id | pubmed-5175685 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2016 |
publisher | International Scientific Literature, Inc. |
record_format | MEDLINE/PubMed |
spelling | pubmed-51756852017-01-03 Emphysema and Airflow Obstruction in Non-Smoking Coal Miners with Pneumoconiosis Altınsoy, Bülent Öz, İbrahim İlker Erboy, Fatma Tor, Meltem Atalay, Figen Med Sci Monit Clinical Research BACKGROUND: Accumulating evidence shows that functional impairment in subjects with coal workers’ pneumoconiosis (CWP) is principally due to emphysema and airflow obstruction, rather than underlying restrictive mechanisms. However, cigarette smoking has remained a major confounder. The aim of this study was to assess whether coal dust exposure was associated with emphysema and/or airflow obstruction in the absence of smoking history. MATERIAL/METHOD: The subjects evaluated for possible pneumoconiosis between 2013 and 2015 were retrospectively enrolled into this study. After excluding those with history of smoking, tuberculosis, or lung cancer, the study population was a total of 57 subjects. The emphysema severity and airflow obstruction were quantified by computed tomographic densitometry analysis and spirometry, respectively. For comparability regarding emphysema, 9 age- and sex-matched nonsmoker (n=9) control subjects without known lung disease were randomly selected from a radiology database. RESULTS: Emphysema severity was significantly higher in the CWP group compared with the control group (15% vs. 4%, p<0.001). The median percent emphysema and percentage of those with FEV1/FVC <0.7 was 13% and 37% in subjects with simple CWP and 18% and 67% in subjects with complicated CWP, respectively. Percent emphysema and Perc15 (15(th) percentile of the attenuation curve) was correlated with FEV1/FVC (r=−0.45, r=−0.47) and FEF25–75 (r=−0.36, r=−0.56), respectively, but not with perfusion score. A linear regression analysis showed that factors associated with emphysema were FEV1/FVC (β=−0.24, p=0.009) and large opacity (β=−3.97, p=0.079), and factors associated with FEV1/FVC were percent emphysema (β=−0.51, p=0.018) and tenure (β=−0.63, p=0.044). CONCLUSIONS: Our results support the observation that coal dust exposure is associated with emphysema and airflow obstruction, independent of smoking status. International Scientific Literature, Inc. 2016-12-13 /pmc/articles/PMC5175685/ /pubmed/27956734 http://dx.doi.org/10.12659/MSM.901820 Text en © Med Sci Monit, 2016 This work is licensed under Creative Common Attribution-NonCommercial-NoDerivatives 4.0 International (CC BY-NC-ND 4.0) |
spellingShingle | Clinical Research Altınsoy, Bülent Öz, İbrahim İlker Erboy, Fatma Tor, Meltem Atalay, Figen Emphysema and Airflow Obstruction in Non-Smoking Coal Miners with Pneumoconiosis |
title | Emphysema and Airflow Obstruction in Non-Smoking Coal Miners with Pneumoconiosis |
title_full | Emphysema and Airflow Obstruction in Non-Smoking Coal Miners with Pneumoconiosis |
title_fullStr | Emphysema and Airflow Obstruction in Non-Smoking Coal Miners with Pneumoconiosis |
title_full_unstemmed | Emphysema and Airflow Obstruction in Non-Smoking Coal Miners with Pneumoconiosis |
title_short | Emphysema and Airflow Obstruction in Non-Smoking Coal Miners with Pneumoconiosis |
title_sort | emphysema and airflow obstruction in non-smoking coal miners with pneumoconiosis |
topic | Clinical Research |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5175685/ https://www.ncbi.nlm.nih.gov/pubmed/27956734 http://dx.doi.org/10.12659/MSM.901820 |
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