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Adsorption of a synthetic TLR7/8 ligand to aluminum oxyhydroxide for enhanced vaccine adjuvant activity: A formulation approach

For nearly a century, aluminum salts have been the most widely used vaccine adjuvant formulation, and have thus established a history of safety and efficacy. Nevertheless, for extremely challenging disease targets such as tuberculosis or HIV, the adjuvant activity of aluminum salts may not be potent...

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Detalles Bibliográficos
Autores principales: Fox, Christopher B., Orr, Mark T., Van Hoeven, Neal, Parker, Sarah C., Mikasa, Traci J.T., Phan, Tony, Beebe, Elyse A., Nana, Ghislain I., Joshi, Sharvari W, Tomai, Mark A., Elvecrog, James, Fouts, Timothy R., Reed, Steven G.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier Science Publishers 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5176129/
https://www.ncbi.nlm.nih.gov/pubmed/27847326
http://dx.doi.org/10.1016/j.jconrel.2016.11.011