Sequence Analysis of Toxin Gene–Bearing Corynebacterium diphtheriae Strains, Australia

By conducting a molecular characterization of Corynebacterium diphtheriae strains in Australia, we identified novel sequences, nonfunctional toxin genes, and 5 recent cases of toxigenic cutaneous diphtheria. These findings highlight the importance of extrapharyngeal infections for toxin gene–bearing...

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Autores principales: Doyle, Christine J., Mazins, Adam, Graham, Rikki M.A., Fang, Ning-Xia, Smith, Helen V., Jennison, Amy V.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Centers for Disease Control and Prevention 2017
Materias:
Dispatch
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5176206/
https://www.ncbi.nlm.nih.gov/pubmed/27983494
http://dx.doi.org/10.3201/eid2301.160584
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author Doyle, Christine J.
Mazins, Adam
Graham, Rikki M.A.
Fang, Ning-Xia
Smith, Helen V.
Jennison, Amy V.
author_facet Doyle, Christine J.
Mazins, Adam
Graham, Rikki M.A.
Fang, Ning-Xia
Smith, Helen V.
Jennison, Amy V.
author_sort Doyle, Christine J.
collection PubMed
description By conducting a molecular characterization of Corynebacterium diphtheriae strains in Australia, we identified novel sequences, nonfunctional toxin genes, and 5 recent cases of toxigenic cutaneous diphtheria. These findings highlight the importance of extrapharyngeal infections for toxin gene–bearing (functional or not) and non–toxin gene–bearing C. diphtheriae strains. Continued surveillance is recommended.
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spelling pubmed-51762062017-01-01 Sequence Analysis of Toxin Gene–Bearing Corynebacterium diphtheriae Strains, Australia Doyle, Christine J. Mazins, Adam Graham, Rikki M.A. Fang, Ning-Xia Smith, Helen V. Jennison, Amy V. Emerg Infect Dis Dispatch By conducting a molecular characterization of Corynebacterium diphtheriae strains in Australia, we identified novel sequences, nonfunctional toxin genes, and 5 recent cases of toxigenic cutaneous diphtheria. These findings highlight the importance of extrapharyngeal infections for toxin gene–bearing (functional or not) and non–toxin gene–bearing C. diphtheriae strains. Continued surveillance is recommended. Centers for Disease Control and Prevention 2017-01 /pmc/articles/PMC5176206/ /pubmed/27983494 http://dx.doi.org/10.3201/eid2301.160584 Text en https://creativecommons.org/licenses/by/4.0/This is a publication of the U.S. Government. This publication is in the public domain and is therefore without copyright. All text from this work may be reprinted freely. Use of these materials should be properly cited.
spellingShingle Dispatch
Doyle, Christine J.
Mazins, Adam
Graham, Rikki M.A.
Fang, Ning-Xia
Smith, Helen V.
Jennison, Amy V.
Sequence Analysis of Toxin Gene–Bearing Corynebacterium diphtheriae Strains, Australia
title Sequence Analysis of Toxin Gene–Bearing Corynebacterium diphtheriae Strains, Australia
title_full Sequence Analysis of Toxin Gene–Bearing Corynebacterium diphtheriae Strains, Australia
title_fullStr Sequence Analysis of Toxin Gene–Bearing Corynebacterium diphtheriae Strains, Australia
title_full_unstemmed Sequence Analysis of Toxin Gene–Bearing Corynebacterium diphtheriae Strains, Australia
title_short Sequence Analysis of Toxin Gene–Bearing Corynebacterium diphtheriae Strains, Australia
title_sort sequence analysis of toxin gene–bearing corynebacterium diphtheriae strains, australia
topic Dispatch
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5176206/
https://www.ncbi.nlm.nih.gov/pubmed/27983494
http://dx.doi.org/10.3201/eid2301.160584
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