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Mass Density Measurement of Mineralized Tissue with Grating-Based X-Ray Phase Tomography
Establishing the mineral content distribution in highly mineralized tissues, such as bones and teeth, is fundamental in understanding a variety of structural questions ranging from studies of the mechanical properties to improved pathological investigations. However, non-destructive, volumetric and...
Autores principales: | , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Public Library of Science
2016
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5176275/ https://www.ncbi.nlm.nih.gov/pubmed/28002416 http://dx.doi.org/10.1371/journal.pone.0167797 |
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author | Gradl, Regine Zanette, Irene Ruiz-Yaniz, Maite Dierolf, Martin Rack, Alexander Zaslansky, Paul Pfeiffer, Franz |
author_facet | Gradl, Regine Zanette, Irene Ruiz-Yaniz, Maite Dierolf, Martin Rack, Alexander Zaslansky, Paul Pfeiffer, Franz |
author_sort | Gradl, Regine |
collection | PubMed |
description | Establishing the mineral content distribution in highly mineralized tissues, such as bones and teeth, is fundamental in understanding a variety of structural questions ranging from studies of the mechanical properties to improved pathological investigations. However, non-destructive, volumetric and quantitative density measurements of mineralized samples, some of which may extend several mm in size, remain challenging. Here, we demonstrate the potential of grating-based x-ray phase tomography to gain insight into the three-dimensional mass density distribution of tooth tissues in a non-destructive way and with a sensitivity of 85 mg/cm(3). Density gradients of 13 − 19% over 1 − 2 mm within typical samples are detected, and local variations in density of 0.4 g/cm(3) on a length scale of 0.1 mm are revealed. This method proves to be an excellent quantitative tool for investigations of subtle differences in mineral content of mineralized tissues that can change following treatment or during ageing and healing. |
format | Online Article Text |
id | pubmed-5176275 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2016 |
publisher | Public Library of Science |
record_format | MEDLINE/PubMed |
spelling | pubmed-51762752017-01-04 Mass Density Measurement of Mineralized Tissue with Grating-Based X-Ray Phase Tomography Gradl, Regine Zanette, Irene Ruiz-Yaniz, Maite Dierolf, Martin Rack, Alexander Zaslansky, Paul Pfeiffer, Franz PLoS One Research Article Establishing the mineral content distribution in highly mineralized tissues, such as bones and teeth, is fundamental in understanding a variety of structural questions ranging from studies of the mechanical properties to improved pathological investigations. However, non-destructive, volumetric and quantitative density measurements of mineralized samples, some of which may extend several mm in size, remain challenging. Here, we demonstrate the potential of grating-based x-ray phase tomography to gain insight into the three-dimensional mass density distribution of tooth tissues in a non-destructive way and with a sensitivity of 85 mg/cm(3). Density gradients of 13 − 19% over 1 − 2 mm within typical samples are detected, and local variations in density of 0.4 g/cm(3) on a length scale of 0.1 mm are revealed. This method proves to be an excellent quantitative tool for investigations of subtle differences in mineral content of mineralized tissues that can change following treatment or during ageing and healing. Public Library of Science 2016-12-21 /pmc/articles/PMC5176275/ /pubmed/28002416 http://dx.doi.org/10.1371/journal.pone.0167797 Text en © 2016 Gradl et al http://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. |
spellingShingle | Research Article Gradl, Regine Zanette, Irene Ruiz-Yaniz, Maite Dierolf, Martin Rack, Alexander Zaslansky, Paul Pfeiffer, Franz Mass Density Measurement of Mineralized Tissue with Grating-Based X-Ray Phase Tomography |
title | Mass Density Measurement of Mineralized Tissue with Grating-Based X-Ray Phase Tomography |
title_full | Mass Density Measurement of Mineralized Tissue with Grating-Based X-Ray Phase Tomography |
title_fullStr | Mass Density Measurement of Mineralized Tissue with Grating-Based X-Ray Phase Tomography |
title_full_unstemmed | Mass Density Measurement of Mineralized Tissue with Grating-Based X-Ray Phase Tomography |
title_short | Mass Density Measurement of Mineralized Tissue with Grating-Based X-Ray Phase Tomography |
title_sort | mass density measurement of mineralized tissue with grating-based x-ray phase tomography |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5176275/ https://www.ncbi.nlm.nih.gov/pubmed/28002416 http://dx.doi.org/10.1371/journal.pone.0167797 |
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