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Overexpression of TIMP-3 in Chondrocytes Produces Transient Reduction in Growth Plate Length but Permanently Reduces Adult Bone Quality and Quantity

Bone development and length relies on the growth plate formation, which is dependent on degradative enzymes such as MMPs. Indeed, deletion of specific members of this enzyme family in mice results in important joint and bone abnormalities, suggesting a role in skeletal development. As such, the cont...

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Detalles Bibliográficos
Autores principales:	Poulet, Blandine, Liu, Ke, Plumb, Darren, Vo, Phoung, Shah, Mittal, Staines, Katherine, Sampson, Alexandra, Nakamura, Hiroyuki, Nagase, Hideaki, Carriero, Alessandra, Shefelbine, Sandra, Pitsillides, Andrew A., Bou-Gharios, George
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2016
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5176305/ https://www.ncbi.nlm.nih.gov/pubmed/28002442 http://dx.doi.org/10.1371/journal.pone.0167971

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