Transient protein-protein interactions perturb E. coli metabolome and cause gene dosage toxicity

Gene dosage toxicity (GDT) is an important factor that determines optimal levels of protein abundances, yet its molecular underpinnings remain unknown. Here, we demonstrate that overexpression of DHFR in E. coli causes a toxic metabolic imbalance triggered by interactions with several functionally r...

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Detalles Bibliográficos
Autores principales: Bhattacharyya, Sanchari, Bershtein, Shimon, Yan, Jin, Argun, Tijda, Gilson, Amy I, Trauger, Sunia A, Shakhnovich, Eugene I
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2016
Materias:
Biophysics and Structural Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5176355/
https://www.ncbi.nlm.nih.gov/pubmed/27938662
http://dx.doi.org/10.7554/eLife.20309

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