Cargando…

Selective Estrogen Receptor Modulators: Cannabinoid Receptor Inverse Agonists with Differential CB1 and CB2 Selectivity

Selective estrogen receptor modulators (SERMs) are used to treat estrogen receptor (ER)-positive breast cancer and osteoporosis. Interestingly, tamoxifen and newer classes of SERMs also exhibit cytotoxic effects in cancers devoid of ERs, indicating a non-estrogenic mechanism of action. Indicative of...

Descripción completa

Detalles Bibliográficos
Autores principales:	Franks, Lirit N., Ford, Benjamin M., Prather, Paul L.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2016
Materias:	Pharmacology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5177629/ https://www.ncbi.nlm.nih.gov/pubmed/28066250 http://dx.doi.org/10.3389/fphar.2016.00503

Ejemplares similares

Cannabinoid CB1 and CB2 Receptor-Mediated Arrestin Translocation: Species, Subtype, and Agonist-Dependence
por: Ibsen, Mikkel Søes, et al.
Publicado: (2019)

Cannabigerol Action at Cannabinoid CB(1) and CB(2) Receptors and at CB(1)–CB(2) Heteroreceptor Complexes
por: Navarro, Gemma, et al.
Publicado: (2018)

Cannabinoids Modulate Neuronal Activity and Cancer by CB1 and CB2 Receptor-Independent Mechanisms
por: Soderstrom, Ken, et al.
Publicado: (2017)

Voltage dependence of the cannabinoid CB1 receptor
por: Goldberger, Esty, et al.
Publicado: (2022)

Editorial: Therapeutic potential of the cannabinoid CB2 receptor
por: Smoum, Reem, et al.
Publicado: (2022)

Modulation of Morphine Analgesia, Antinociceptive Tolerance, and Mu-Opioid Receptor Binding by the Cannabinoid CB2 Receptor Agonist O-1966
por: Reichenbach, Zachary W., et al.
Publicado: (2022)

On the Role of Cannabinoid CB1- and μ-Opioid Receptors in Motor Impulsivity
por: Wiskerke, Joost, et al.
Publicado: (2012)

Evaluating signaling bias for synthetic cannabinoid receptor agonists at the cannabinoid CB(2) receptor
por: Patel, Monica, et al.
Publicado: (2023)

Chain Substituted Cannabilactones with Selectivity for the CB2 Cannabinoid Receptor
por: Alapafuja, Shakiru O., et al.
Publicado: (2019)

Structural basis of selective cannabinoid CB(2) receptor activation
por: Li, Xiaoting, et al.
Publicado: (2023)

Positive Allosteric Modulation of CB1 and CB2 Cannabinoid Receptors Enhances the Neuroprotective Activity of a Dual CB1R/CB2R Orthosteric Agonist
por: Polini, Beatrice, et al.
Publicado: (2020)

Cannabinoid CB(1) and CB(2) Receptor Signaling and Bias
por: Ibsen, Mikkel Søes, et al.
Publicado: (2017)

Anti-inflammatory and antinociceptive effects of the selective cannabinoid CB(2) receptor agonist ABK5
por: Tang, Yaliang, et al.
Publicado: (2020)

Characterization of Subtype Selective Cannabinoid CB(2) Receptor Agonists as Potential Anti-Inflammatory Agents
por: Tang, Yaliang, et al.
Publicado: (2021)

Cannabinoid Receptors CB1 and CB2 Modulate the Electroretinographic Waves in Vervet Monkeys
por: Bouskila, Joseph, et al.
Publicado: (2016)

Pharmacological Properties, Therapeutic Potential and Molecular Mechanisms of JWH133, a CB2 Receptor-Selective Agonist
por: Hashiesh, Hebaallah Mamdouh, et al.
Publicado: (2021)

Evaluation of carboxamide-type synthetic cannabinoids as CB(1)/CB(2) receptor agonists: difference between the enantiomers
por: Doi, Takahiro, et al.
Publicado: (2017)

Cannabinoid Receptor CB(2) Modulates Axon Guidance
por: Duff, Gabriel, et al.
Publicado: (2013)

Microglial Cannabinoid CB(2) Receptors in Pain Modulation
por: Xu, Kangtai, et al.
Publicado: (2023)

CB1 Cannabinoid Receptor Expression in the Striatum: Association with Corticostriatal Circuits and Developmental Regulation
por: Van Waes, Vincent, et al.
Publicado: (2012)

Cannabinoid Receptor 2 (CB2) Inverse Agonist SMM-189 Induces Expression of Endogenous CB2 and Protein Kinase A That Differentially Modulates the Immune Response and Suppresses Experimental Colitis
por: Kiran, Sonia, et al.
Publicado: (2022)

Functional characterization of the novel cannabinoid receptor GPR55 and its modulation by CB(1 )and CB(2 )receptors
por: Balenga, Nariman, et al.
Publicado: (2008)

Cannabinoid CB(2) Receptors Modulate Microglia Function and Amyloid Dynamics in a Mouse Model of Alzheimer’s Disease
por: Ruiz de Martín Esteban, Samuel, et al.
Publicado: (2022)

Exploring determinants of agonist efficacy at the CB1 cannabinoid receptor: Analogues of the synthetic cannabinoid receptor agonist EG‐018
por: Finlay, David B., et al.
Publicado: (2022)

2-Arylpropionic Acid Pyrazolamides as Cannabinoid CB2 Receptor Inverse Agonists Endowed with Anti-Inflammatory Properties
por: de Oliveira, Daniela R., et al.
Publicado: (2022)

Tamoxifen Isomers and Metabolites Exhibit Distinct Affinity and Activity at Cannabinoid Receptors: Potential Scaffold for Drug Development
por: Ford, Benjamin M., et al.
Publicado: (2016)

Electroacupuncture reduces chronic itch via cannabinoid CB1 receptors in the ventrolateral periaqueductal gray
por: Ge, Wen-Qiang, et al.
Publicado: (2022)

Cannabinoid 1 (CB(1)) receptor arrestin subtype‐selectivity and phosphorylation dependence
por: Manning, Jamie J., et al.
Publicado: (2022)

Cholesterol as a modulator of cannabinoid receptor CB(2) signaling
por: Yeliseev, Alexei, et al.
Publicado: (2021)

Anti-Inflammatory and Pro-Autophagy Effects of the Cannabinoid Receptor CB2R: Possibility of Modulation in Type 1 Diabetes
por: Liu, Qing-Rong, et al.
Publicado: (2022)

Cannabinoid CB1 receptors regulate salivation
por: Andreis, Kelsey, et al.
Publicado: (2022)

Binding and Signaling Studies Disclose a Potential Allosteric Site for Cannabidiol in Cannabinoid CB(2) Receptors
por: Martínez-Pinilla, Eva, et al.
Publicado: (2017)

Anti-Proliferative Properties and Proapoptotic Function of New CB2 Selective Cannabinoid Receptor Agonist in Jurkat Leukemia Cells
por: Capozzi, Antonella, et al.
Publicado: (2018)

Synthesis and In Vitro Characterization of Selective Cannabinoid CB2 Receptor Agonists: Biological Evaluation against Neuroblastoma Cancer Cells
por: Gado, Francesca, et al.
Publicado: (2022)

3D-QSAR/CoMFA-Based Structure-Affinity/Selectivity Relationships of Aminoalkylindoles in the Cannabinoid CB1 and CB2 Receptors
por: Mella-Raipán, Jaime, et al.
Publicado: (2014)

Functional Selectivity of a Biased Cannabinoid-1 Receptor (CB(1)R) Antagonist
por: Liu, Ziyi, et al.
Publicado: (2021)

PM288. Preclinical Evaluation of Neutral Cannabinoid CB1 Receptor Antagonists and Cannabinoid CB1 Receptor Negative Allosteric Modulators for Treating Drug Addiction
por: Gardner, Eliot L., et al.
Publicado: (2016)

Cannabinoid CB1 receptor agonist ACEA alleviates brain ischemia/reperfusion injury via CB1–Drp1 pathway
por: Yang, Shuai, et al.
Publicado: (2020)

Expression and Function of Cannabinoid Receptors CB1 and CB2 and Their Cognate Cannabinoid Ligands in Murine Embryonic Stem Cells
por: Jiang, Shuxian, et al.
Publicado: (2007)

Brain Cannabinoid CB(2) Receptors Modulate Cocaine’s Actions in Mice
por: Xi, Zheng-Xiong, et al.
Publicado: (2011)

Cannot write session to /tmp/vufind_sessions/sess_tj0sgrtthphfpn0iqpvg82ktlj