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Relation between Acute GVHD and NK Cell Subset Reconstitution Following Allogeneic Stem Cell Transplantation
One of the major challenges of allogeneic stem cell transplantation (allo-SCT) is to reduce the risk of graft-versus-host disease (GVHD) while boosting the graft-versus-leukemia (GVL) effect. The reconstitution of natural killer (NK) cells following allo-SCT is of notable interest due to their known...
Autores principales: | , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Frontiers Media S.A.
2016
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5177660/ https://www.ncbi.nlm.nih.gov/pubmed/28066411 http://dx.doi.org/10.3389/fimmu.2016.00595 |
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author | Ullrich, Evelyn Salzmann-Manrique, Emilia Bakhtiar, Shahrzad Bremm, Melanie Gerstner, Stephanie Herrmann, Eva Bader, Peter Hoffmann, Petra Holler, Ernst Edinger, Matthias Wolff, Daniel |
author_facet | Ullrich, Evelyn Salzmann-Manrique, Emilia Bakhtiar, Shahrzad Bremm, Melanie Gerstner, Stephanie Herrmann, Eva Bader, Peter Hoffmann, Petra Holler, Ernst Edinger, Matthias Wolff, Daniel |
author_sort | Ullrich, Evelyn |
collection | PubMed |
description | One of the major challenges of allogeneic stem cell transplantation (allo-SCT) is to reduce the risk of graft-versus-host disease (GVHD) while boosting the graft-versus-leukemia (GVL) effect. The reconstitution of natural killer (NK) cells following allo-SCT is of notable interest due to their known capability to induce GVL without GVHD. Here, in this study, we investigate the association between the incidence and severity of acute graft-versus-host disease (aGVHD) and the early reconstitution of NK cell subsets following allo-SCT. We analyzed 342 samples from 107 patients using flow cytometry, with a focus on immature CD56(high) and mature cytotoxic CD56(dim) NK cells. Longitudinal analysis of immune reconstitution after allo-SCT showed that the incidence of aGVHD was associated with a delayed expansion of the entire NK cell population, in particular the CD56(high) subset. Notably, the disturbed reconstitution of the CD56(high) NK cells also correlated with the severity of aGVHD. |
format | Online Article Text |
id | pubmed-5177660 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2016 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-51776602017-01-06 Relation between Acute GVHD and NK Cell Subset Reconstitution Following Allogeneic Stem Cell Transplantation Ullrich, Evelyn Salzmann-Manrique, Emilia Bakhtiar, Shahrzad Bremm, Melanie Gerstner, Stephanie Herrmann, Eva Bader, Peter Hoffmann, Petra Holler, Ernst Edinger, Matthias Wolff, Daniel Front Immunol Immunology One of the major challenges of allogeneic stem cell transplantation (allo-SCT) is to reduce the risk of graft-versus-host disease (GVHD) while boosting the graft-versus-leukemia (GVL) effect. The reconstitution of natural killer (NK) cells following allo-SCT is of notable interest due to their known capability to induce GVL without GVHD. Here, in this study, we investigate the association between the incidence and severity of acute graft-versus-host disease (aGVHD) and the early reconstitution of NK cell subsets following allo-SCT. We analyzed 342 samples from 107 patients using flow cytometry, with a focus on immature CD56(high) and mature cytotoxic CD56(dim) NK cells. Longitudinal analysis of immune reconstitution after allo-SCT showed that the incidence of aGVHD was associated with a delayed expansion of the entire NK cell population, in particular the CD56(high) subset. Notably, the disturbed reconstitution of the CD56(high) NK cells also correlated with the severity of aGVHD. Frontiers Media S.A. 2016-12-22 /pmc/articles/PMC5177660/ /pubmed/28066411 http://dx.doi.org/10.3389/fimmu.2016.00595 Text en Copyright © 2016 Ullrich, Salzmann-Manrique, Bakhtiar, Bremm, Gerstner, Herrmann, Bader, Hoffmann, Holler, Edinger and Wolff. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Immunology Ullrich, Evelyn Salzmann-Manrique, Emilia Bakhtiar, Shahrzad Bremm, Melanie Gerstner, Stephanie Herrmann, Eva Bader, Peter Hoffmann, Petra Holler, Ernst Edinger, Matthias Wolff, Daniel Relation between Acute GVHD and NK Cell Subset Reconstitution Following Allogeneic Stem Cell Transplantation |
title | Relation between Acute GVHD and NK Cell Subset Reconstitution Following Allogeneic Stem Cell Transplantation |
title_full | Relation between Acute GVHD and NK Cell Subset Reconstitution Following Allogeneic Stem Cell Transplantation |
title_fullStr | Relation between Acute GVHD and NK Cell Subset Reconstitution Following Allogeneic Stem Cell Transplantation |
title_full_unstemmed | Relation between Acute GVHD and NK Cell Subset Reconstitution Following Allogeneic Stem Cell Transplantation |
title_short | Relation between Acute GVHD and NK Cell Subset Reconstitution Following Allogeneic Stem Cell Transplantation |
title_sort | relation between acute gvhd and nk cell subset reconstitution following allogeneic stem cell transplantation |
topic | Immunology |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5177660/ https://www.ncbi.nlm.nih.gov/pubmed/28066411 http://dx.doi.org/10.3389/fimmu.2016.00595 |
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