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Effects of initial telomere length distribution on senescence onset and heterogeneity
Replicative senescence, induced by telomere shortening, exhibits considerable asynchrony and heterogeneity, the origins of which remain unclear. Here, we formally study how telomere shortening mechanisms impact on senescence kinetics and define two regimes of senescence, depending on the initial tel...
| Autores principales: | , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Elsevier
2017
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5177728/ https://www.ncbi.nlm.nih.gov/pubmed/27864096 http://dx.doi.org/10.1016/j.jtbi.2016.11.010 |