The spliceosome U2 snRNP factors promote genome stability through distinct mechanisms; transcription of repair factors and R-loop processing

Recent whole-exome sequencing of malignancies have detected recurrent somatic mutations in U2 small nuclear ribonucleoprotein complex (snRNP) components of the spliceosome. These factors have also been identified as novel players in the DNA-damage response (DDR) in several genome-wide screens and pr...

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Detalles Bibliográficos
Autores principales: Tanikawa, M, Sanjiv, K, Helleday, T, Herr, P, Mortusewicz, O
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2016
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5177769/
https://www.ncbi.nlm.nih.gov/pubmed/27991914
http://dx.doi.org/10.1038/oncsis.2016.70

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