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hMYH and hMTH1 cooperate for survival in mismatch repair defective T-cell acute lymphoblastic leukemia

hMTH1 is an 8-oxodGTPase that prevents mis-incorporation of free oxidized nucleotides into genomic DNA. Base excision and mismatch repair pathways also restrict the accumulation of oxidized lesions in DNA by removing the mis-inserted 8-oxo-7,8-dihydro-2'-deoxyguanosines (8-oxodGs). In this stud...

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Detalles Bibliográficos
Autores principales:	Eshtad, S, Mavajian, Z, Rudd, S G, Visnes, T, Boström, J, Altun, M, Helleday, T
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group 2016
Materias:	Original Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5177770/ https://www.ncbi.nlm.nih.gov/pubmed/27918552 http://dx.doi.org/10.1038/oncsis.2016.72

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