Linking genomic reorganization to tumor initiation via the giant cell cycle

To investigate the mechanisms underlying our recent paradoxical finding that mitotically incapacitated and genomically unstable polyploid giant cancer cells (PGCCs) are capable of tumor initiation, we labeled ovarian cancer cells with α-tubulin fused to green fluorescent protein, histone-2B fused to...

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Detalles Bibliográficos
Autores principales: Niu, N, Zhang, J, Zhang, N, Mercado-Uribe, I, Tao, F, Han, Z, Pathak, S, Multani, A S, Kuang, J, Yao, J, Bast, R C, Sood, A K, Hung, M-C, Liu, J
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2016
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5177773/
https://www.ncbi.nlm.nih.gov/pubmed/27991913
http://dx.doi.org/10.1038/oncsis.2016.75

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