Hepatocarcinogenesis in transgenic mice carrying hepatitis B virus pre-S/S gene with the sW172* mutation

Hepatitis B virus (HBV) carrying the rtA181T/sW172* mutation conferred cross-resistance to adefovir and lamivudine. Cell-based and clinical studies indicated that HBV carrying this mutation had an increased oncogenic potential. Herein, we created transgenic mouse models to study the oncogenicity of...

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Detalles Bibliográficos
Autores principales: Lai, M-W, Liang, K-H, Lin, W-R, Huang, Y-H, Huang, S-F, Chen, T-C, Yeh, C-T
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2016
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5177775/
https://www.ncbi.nlm.nih.gov/pubmed/27918551
http://dx.doi.org/10.1038/oncsis.2016.77

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