Tyrosine Hydroxylase Binding to Phospholipid Membranes Prompts Its Amyloid Aggregation and Compromises Bilayer Integrity

Tyrosine hydroxylase (TH), a rate-limiting enzyme in the synthesis of catecholamine neurotransmitters and hormones, binds to negatively charged phospholipid membranes. Binding to both large and giant unilamellar vesicles causes membrane permeabilization, as observed by efflux and influx of fluoresce...

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Detalles Bibliográficos
Autores principales: Baumann, Anne, Jorge-Finnigan, Ana, Jung-KC, Kunwar, Sauter, Alexander, Horvath, Istvan, Morozova-Roche, Ludmilla A., Martinez, Aurora
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5177901/
https://www.ncbi.nlm.nih.gov/pubmed/28004763
http://dx.doi.org/10.1038/srep39488

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