The citrus flavonoid naringenin confers protection in a murine endotoxaemia model through AMPK-ATF3-dependent negative regulation of the TLR4 signalling pathway

Excessive activation of the TLR4 signalling pathway is critical for inflammation-associated disorders, while negative regulators play key roles in restraining TLR4 from over-activation. Naringenin is a citrus flavonoid with remarkable anti-inflammatory activity, but the mechanisms underlying its inh...

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Detalles Bibliográficos
Autores principales: Liu, Xin, Wang, Ning, Fan, Shijun, Zheng, Xinchuan, Yang, Yongjun, Zhu, Yuanfeng, Lu, Yongling, Chen, Qian, Zhou, Hong, Zheng, Jiang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5177915/
https://www.ncbi.nlm.nih.gov/pubmed/28004841
http://dx.doi.org/10.1038/srep39735

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