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Composition of the Hemagglutinin Polybasic Proteolytic Cleavage Motif Mediates Variable Virulence of H7N7 Avian Influenza Viruses
Acquisition of a polybasic cleavage site (pCS) in the hemagglutinin (HA) is a prerequisite for the shift of low pathogenic (LP) avian influenza virus (AIV) to the highly pathogenic (HP) form in chickens. Whereas presence of a pCS is required for high pathogenicity, less is known about the effect of...
Autores principales: | Abdelwhab, E. M., Veits, Jutta, Ulrich, Reiner, Kasbohm, Elisa, Teifke, Jens P., Mettenleiter, Thomas C. |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group
2016
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5177941/ https://www.ncbi.nlm.nih.gov/pubmed/28004772 http://dx.doi.org/10.1038/srep39505 |
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