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Insulin therapy in patients with cystic fibrosis in the pre-diabetes stage: a systematic review
OBJECTIVE: To elucidate whether insulin is effective or not in patients with cystic fibrosis before the diabetes mellitus phase. DATA SOURCE: The study was performed according to the Prisma method between August and September 2014, using the PubMed, Embase, Lilacs and SciELO databases. Prospective s...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Sociedade de Pediatria de São Paulo
2016
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5178124/ https://www.ncbi.nlm.nih.gov/pubmed/26994743 http://dx.doi.org/10.1016/j.rppede.2016.03.006 |
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author | Pu, Mariana Zorrón Mei Hsia Christensen-Adad, Flávia Corrêa Gonçalves, Aline Cristina Minicucci, Walter José Ribeiro, José Dirceu Ribeiro, Antonio Fernando |
author_facet | Pu, Mariana Zorrón Mei Hsia Christensen-Adad, Flávia Corrêa Gonçalves, Aline Cristina Minicucci, Walter José Ribeiro, José Dirceu Ribeiro, Antonio Fernando |
author_sort | Pu, Mariana Zorrón Mei Hsia |
collection | PubMed |
description | OBJECTIVE: To elucidate whether insulin is effective or not in patients with cystic fibrosis before the diabetes mellitus phase. DATA SOURCE: The study was performed according to the Prisma method between August and September 2014, using the PubMed, Embase, Lilacs and SciELO databases. Prospective studies published in English, Portuguese and Spanish from 2002 to 2014, evaluating the effect of insulin on weight parameters, body mass index and pulmonary function in patients with cystic fibrosis, with a mean age of 17.37 years before the diabetes mellitus phase were included. DATA SYNTHESIS: Eight articles were identified that included 180 patients undergoing insulin use. Sample size ranged from 4 to 54 patients, with a mean age ranging from 12.4 to 28 years. The type of follow-up, time of insulin use, the dose and implementation schedule were very heterogeneous between studies. CONCLUSIONS: There are theoretical reasons to believe that insulin has a beneficial effect in the studied population. The different methods and populations assessed in the studies do not allow us to state whether early insulin therapy should or should not be carried out in patients with cystic fibrosis prior to the diagnosis of diabetes. Therefore, studies with larger samples and insulin use standardization are required. |
format | Online Article Text |
id | pubmed-5178124 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2016 |
publisher | Sociedade de Pediatria de São Paulo |
record_format | MEDLINE/PubMed |
spelling | pubmed-51781242017-01-04 Insulin therapy in patients with cystic fibrosis in the pre-diabetes stage: a systematic review Pu, Mariana Zorrón Mei Hsia Christensen-Adad, Flávia Corrêa Gonçalves, Aline Cristina Minicucci, Walter José Ribeiro, José Dirceu Ribeiro, Antonio Fernando Rev Paul Pediatr Review Articles OBJECTIVE: To elucidate whether insulin is effective or not in patients with cystic fibrosis before the diabetes mellitus phase. DATA SOURCE: The study was performed according to the Prisma method between August and September 2014, using the PubMed, Embase, Lilacs and SciELO databases. Prospective studies published in English, Portuguese and Spanish from 2002 to 2014, evaluating the effect of insulin on weight parameters, body mass index and pulmonary function in patients with cystic fibrosis, with a mean age of 17.37 years before the diabetes mellitus phase were included. DATA SYNTHESIS: Eight articles were identified that included 180 patients undergoing insulin use. Sample size ranged from 4 to 54 patients, with a mean age ranging from 12.4 to 28 years. The type of follow-up, time of insulin use, the dose and implementation schedule were very heterogeneous between studies. CONCLUSIONS: There are theoretical reasons to believe that insulin has a beneficial effect in the studied population. The different methods and populations assessed in the studies do not allow us to state whether early insulin therapy should or should not be carried out in patients with cystic fibrosis prior to the diagnosis of diabetes. Therefore, studies with larger samples and insulin use standardization are required. Sociedade de Pediatria de São Paulo 2016 /pmc/articles/PMC5178124/ /pubmed/26994743 http://dx.doi.org/10.1016/j.rppede.2016.03.006 Text en © 2016 Sociedade de Pediatria de São Paulo. Published by Elsevier Editora Ltda http://creativecommons.org/licenses/by/4.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Review Articles Pu, Mariana Zorrón Mei Hsia Christensen-Adad, Flávia Corrêa Gonçalves, Aline Cristina Minicucci, Walter José Ribeiro, José Dirceu Ribeiro, Antonio Fernando Insulin therapy in patients with cystic fibrosis in the pre-diabetes stage: a systematic review |
title | Insulin therapy in patients with cystic fibrosis in the pre-diabetes stage: a systematic review |
title_full | Insulin therapy in patients with cystic fibrosis in the pre-diabetes stage: a systematic review |
title_fullStr | Insulin therapy in patients with cystic fibrosis in the pre-diabetes stage: a systematic review |
title_full_unstemmed | Insulin therapy in patients with cystic fibrosis in the pre-diabetes stage: a systematic review |
title_short | Insulin therapy in patients with cystic fibrosis in the pre-diabetes stage: a systematic review |
title_sort | insulin therapy in patients with cystic fibrosis in the pre-diabetes stage: a systematic review |
topic | Review Articles |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5178124/ https://www.ncbi.nlm.nih.gov/pubmed/26994743 http://dx.doi.org/10.1016/j.rppede.2016.03.006 |
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