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Hypoxic Stress Forces Irreversible Differentiation of a Majority of Mouse Trophoblast Stem Cells Despite FGF4

Hypoxic, hyperosmotic, and genotoxic stress slow mouse trophoblast stem cell (mTSC) proliferation, decrease potency/stemness, and increase differentiation. Previous reports suggest a period of reversibility in stress-induced mTSC differentiation. Here we show that hypoxic stress at 0.5% O(2) decreas...

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Detalles Bibliográficos
Autores principales:	Yang, Yu, Arenas-Hernandez, Marcia, Gomez-Lopez, Nardhy, Dai, Jing, Parker, Graham C., Puscheck, Elizabeth E., Rappolee, Daniel A.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Society for the Study of Reproduction, Inc. 2016
Materias:	Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5178149/ https://www.ncbi.nlm.nih.gov/pubmed/27683262 http://dx.doi.org/10.1095/biolreprod.116.138412

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