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Risk of lung cancer in patients with gastro-esophageal reflux disease: a population-based cohort study
This large-scale, controlled cohort study estimated the risks of lung cancer in patients with gastro-esophageal reflux disease (GERD) in Taiwan. We conducted this population-based study using data from the National Health Insurance Research Database of Taiwan during the period from 1997 to 2010. Pat...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
PeerJ Inc.
2016
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5178340/ https://www.ncbi.nlm.nih.gov/pubmed/28028458 http://dx.doi.org/10.7717/peerj.2753 |
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author | Hsu, Chi-Kuei Lai, Chih-Cheng Wang, Kun Chen, Likwang |
author_facet | Hsu, Chi-Kuei Lai, Chih-Cheng Wang, Kun Chen, Likwang |
author_sort | Hsu, Chi-Kuei |
collection | PubMed |
description | This large-scale, controlled cohort study estimated the risks of lung cancer in patients with gastro-esophageal reflux disease (GERD) in Taiwan. We conducted this population-based study using data from the National Health Insurance Research Database of Taiwan during the period from 1997 to 2010. Patients with GERD were diagnosed using endoscopy, and controls were matched to patients with GERD at a ratio of 1:4. We identified 15,412 patients with GERD and 60,957 controls. Compared with the controls, the patients with GERD had higher rates of osteoporosis, diabetes mellitus, asthma, chronic obstructive pulmonary disease, pneumonia, bronchiectasis, depression, anxiety, hypertension, dyslipidemia, chronic liver disease, congestive heart failure, atrial fibrillation, stroke, chronic kidney disease, and coronary artery disease (all P < .05). A total of 85 patients had lung cancer among patients with GERD during the follow-up of 42,555 person-years, and the rate of lung cancer was 0.0020 per person-year. By contrast, 232 patients had lung cancer among patients without GERD during the follow-up of 175,319 person-years, and the rate of lung cancer was 0.0013 per person-year. By using stepwise Cox regression model, the overall incidence of lung cancer remained significantly higher in the patients with GERD than in the controls (hazard ratio, 1.53; 95% CI [1.19–1.98]). The cumulative incidence of lung cancer was higher in the patients with GERD than in the controls (P = .0012). In conclusion, our large population-based cohort study provides evidence that GERD may increase the risk of lung cancer in Asians. |
format | Online Article Text |
id | pubmed-5178340 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2016 |
publisher | PeerJ Inc. |
record_format | MEDLINE/PubMed |
spelling | pubmed-51783402016-12-27 Risk of lung cancer in patients with gastro-esophageal reflux disease: a population-based cohort study Hsu, Chi-Kuei Lai, Chih-Cheng Wang, Kun Chen, Likwang PeerJ Epidemiology This large-scale, controlled cohort study estimated the risks of lung cancer in patients with gastro-esophageal reflux disease (GERD) in Taiwan. We conducted this population-based study using data from the National Health Insurance Research Database of Taiwan during the period from 1997 to 2010. Patients with GERD were diagnosed using endoscopy, and controls were matched to patients with GERD at a ratio of 1:4. We identified 15,412 patients with GERD and 60,957 controls. Compared with the controls, the patients with GERD had higher rates of osteoporosis, diabetes mellitus, asthma, chronic obstructive pulmonary disease, pneumonia, bronchiectasis, depression, anxiety, hypertension, dyslipidemia, chronic liver disease, congestive heart failure, atrial fibrillation, stroke, chronic kidney disease, and coronary artery disease (all P < .05). A total of 85 patients had lung cancer among patients with GERD during the follow-up of 42,555 person-years, and the rate of lung cancer was 0.0020 per person-year. By contrast, 232 patients had lung cancer among patients without GERD during the follow-up of 175,319 person-years, and the rate of lung cancer was 0.0013 per person-year. By using stepwise Cox regression model, the overall incidence of lung cancer remained significantly higher in the patients with GERD than in the controls (hazard ratio, 1.53; 95% CI [1.19–1.98]). The cumulative incidence of lung cancer was higher in the patients with GERD than in the controls (P = .0012). In conclusion, our large population-based cohort study provides evidence that GERD may increase the risk of lung cancer in Asians. PeerJ Inc. 2016-12-20 /pmc/articles/PMC5178340/ /pubmed/28028458 http://dx.doi.org/10.7717/peerj.2753 Text en ©2016 Hsu et al. http://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, reproduction and adaptation in any medium and for any purpose provided that it is properly attributed. For attribution, the original author(s), title, publication source (PeerJ) and either DOI or URL of the article must be cited. |
spellingShingle | Epidemiology Hsu, Chi-Kuei Lai, Chih-Cheng Wang, Kun Chen, Likwang Risk of lung cancer in patients with gastro-esophageal reflux disease: a population-based cohort study |
title | Risk of lung cancer in patients with gastro-esophageal reflux disease: a population-based cohort study |
title_full | Risk of lung cancer in patients with gastro-esophageal reflux disease: a population-based cohort study |
title_fullStr | Risk of lung cancer in patients with gastro-esophageal reflux disease: a population-based cohort study |
title_full_unstemmed | Risk of lung cancer in patients with gastro-esophageal reflux disease: a population-based cohort study |
title_short | Risk of lung cancer in patients with gastro-esophageal reflux disease: a population-based cohort study |
title_sort | risk of lung cancer in patients with gastro-esophageal reflux disease: a population-based cohort study |
topic | Epidemiology |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5178340/ https://www.ncbi.nlm.nih.gov/pubmed/28028458 http://dx.doi.org/10.7717/peerj.2753 |
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