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Risk of lung cancer in patients with gastro-esophageal reflux disease: a population-based cohort study

This large-scale, controlled cohort study estimated the risks of lung cancer in patients with gastro-esophageal reflux disease (GERD) in Taiwan. We conducted this population-based study using data from the National Health Insurance Research Database of Taiwan during the period from 1997 to 2010. Pat...

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Autores principales: Hsu, Chi-Kuei, Lai, Chih-Cheng, Wang, Kun, Chen, Likwang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: PeerJ Inc. 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5178340/
https://www.ncbi.nlm.nih.gov/pubmed/28028458
http://dx.doi.org/10.7717/peerj.2753
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author Hsu, Chi-Kuei
Lai, Chih-Cheng
Wang, Kun
Chen, Likwang
author_facet Hsu, Chi-Kuei
Lai, Chih-Cheng
Wang, Kun
Chen, Likwang
author_sort Hsu, Chi-Kuei
collection PubMed
description This large-scale, controlled cohort study estimated the risks of lung cancer in patients with gastro-esophageal reflux disease (GERD) in Taiwan. We conducted this population-based study using data from the National Health Insurance Research Database of Taiwan during the period from 1997 to 2010. Patients with GERD were diagnosed using endoscopy, and controls were matched to patients with GERD at a ratio of 1:4. We identified 15,412 patients with GERD and 60,957 controls. Compared with the controls, the patients with GERD had higher rates of osteoporosis, diabetes mellitus, asthma, chronic obstructive pulmonary disease, pneumonia, bronchiectasis, depression, anxiety, hypertension, dyslipidemia, chronic liver disease, congestive heart failure, atrial fibrillation, stroke, chronic kidney disease, and coronary artery disease (all P < .05). A total of 85 patients had lung cancer among patients with GERD during the follow-up of 42,555 person-years, and the rate of lung cancer was 0.0020 per person-year. By contrast, 232 patients had lung cancer among patients without GERD during the follow-up of 175,319 person-years, and the rate of lung cancer was 0.0013 per person-year. By using stepwise Cox regression model, the overall incidence of lung cancer remained significantly higher in the patients with GERD than in the controls (hazard ratio, 1.53; 95% CI [1.19–1.98]). The cumulative incidence of lung cancer was higher in the patients with GERD than in the controls (P = .0012). In conclusion, our large population-based cohort study provides evidence that GERD may increase the risk of lung cancer in Asians.
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spelling pubmed-51783402016-12-27 Risk of lung cancer in patients with gastro-esophageal reflux disease: a population-based cohort study Hsu, Chi-Kuei Lai, Chih-Cheng Wang, Kun Chen, Likwang PeerJ Epidemiology This large-scale, controlled cohort study estimated the risks of lung cancer in patients with gastro-esophageal reflux disease (GERD) in Taiwan. We conducted this population-based study using data from the National Health Insurance Research Database of Taiwan during the period from 1997 to 2010. Patients with GERD were diagnosed using endoscopy, and controls were matched to patients with GERD at a ratio of 1:4. We identified 15,412 patients with GERD and 60,957 controls. Compared with the controls, the patients with GERD had higher rates of osteoporosis, diabetes mellitus, asthma, chronic obstructive pulmonary disease, pneumonia, bronchiectasis, depression, anxiety, hypertension, dyslipidemia, chronic liver disease, congestive heart failure, atrial fibrillation, stroke, chronic kidney disease, and coronary artery disease (all P < .05). A total of 85 patients had lung cancer among patients with GERD during the follow-up of 42,555 person-years, and the rate of lung cancer was 0.0020 per person-year. By contrast, 232 patients had lung cancer among patients without GERD during the follow-up of 175,319 person-years, and the rate of lung cancer was 0.0013 per person-year. By using stepwise Cox regression model, the overall incidence of lung cancer remained significantly higher in the patients with GERD than in the controls (hazard ratio, 1.53; 95% CI [1.19–1.98]). The cumulative incidence of lung cancer was higher in the patients with GERD than in the controls (P = .0012). In conclusion, our large population-based cohort study provides evidence that GERD may increase the risk of lung cancer in Asians. PeerJ Inc. 2016-12-20 /pmc/articles/PMC5178340/ /pubmed/28028458 http://dx.doi.org/10.7717/peerj.2753 Text en ©2016 Hsu et al. http://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, reproduction and adaptation in any medium and for any purpose provided that it is properly attributed. For attribution, the original author(s), title, publication source (PeerJ) and either DOI or URL of the article must be cited.
spellingShingle Epidemiology
Hsu, Chi-Kuei
Lai, Chih-Cheng
Wang, Kun
Chen, Likwang
Risk of lung cancer in patients with gastro-esophageal reflux disease: a population-based cohort study
title Risk of lung cancer in patients with gastro-esophageal reflux disease: a population-based cohort study
title_full Risk of lung cancer in patients with gastro-esophageal reflux disease: a population-based cohort study
title_fullStr Risk of lung cancer in patients with gastro-esophageal reflux disease: a population-based cohort study
title_full_unstemmed Risk of lung cancer in patients with gastro-esophageal reflux disease: a population-based cohort study
title_short Risk of lung cancer in patients with gastro-esophageal reflux disease: a population-based cohort study
title_sort risk of lung cancer in patients with gastro-esophageal reflux disease: a population-based cohort study
topic Epidemiology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5178340/
https://www.ncbi.nlm.nih.gov/pubmed/28028458
http://dx.doi.org/10.7717/peerj.2753
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