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Urinary Bladder Cancer: Biomarkers and Target Therapy, New Era for More Attention
Currently, bladder cancer (BCa) evaluation depends mainly on traditional clinicopathological parameters encompassing tumor stage and grade, which will not reflect the behavior of the disease. Diverse molecular alterations are responsible for the heterogeneous course. The differences in molecular pat...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
PAGEPress Publications, Pavia, Italy
2016
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5178843/ https://www.ncbi.nlm.nih.gov/pubmed/28058098 http://dx.doi.org/10.4081/oncol.2016.320 |
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author | Mohammed, Amrallah A. EL-Tanni, Hani EL-Khatib, Hani M. Mirza, Ahmad A. Mirza, Abdulrahim A. Alturaifi, Turki H. |
author_facet | Mohammed, Amrallah A. EL-Tanni, Hani EL-Khatib, Hani M. Mirza, Ahmad A. Mirza, Abdulrahim A. Alturaifi, Turki H. |
author_sort | Mohammed, Amrallah A. |
collection | PubMed |
description | Currently, bladder cancer (BCa) evaluation depends mainly on traditional clinicopathological parameters encompassing tumor stage and grade, which will not reflect the behavior of the disease. Diverse molecular alterations are responsible for the heterogeneous course. The differences in molecular pathogenesis between non-invasive BCa and invasive BCa have been recognized. Molecular biomarkers are promising to predict progression and survival. The management of advanced BCa remains somewhat primitive in comparison with other more common malignancies. This topic will discuss the molecular pathways, biomarkers and potential targets that may improve the outcome in BCa. |
format | Online Article Text |
id | pubmed-5178843 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2016 |
publisher | PAGEPress Publications, Pavia, Italy |
record_format | MEDLINE/PubMed |
spelling | pubmed-51788432017-01-05 Urinary Bladder Cancer: Biomarkers and Target Therapy, New Era for More Attention Mohammed, Amrallah A. EL-Tanni, Hani EL-Khatib, Hani M. Mirza, Ahmad A. Mirza, Abdulrahim A. Alturaifi, Turki H. Oncol Rev Review Currently, bladder cancer (BCa) evaluation depends mainly on traditional clinicopathological parameters encompassing tumor stage and grade, which will not reflect the behavior of the disease. Diverse molecular alterations are responsible for the heterogeneous course. The differences in molecular pathogenesis between non-invasive BCa and invasive BCa have been recognized. Molecular biomarkers are promising to predict progression and survival. The management of advanced BCa remains somewhat primitive in comparison with other more common malignancies. This topic will discuss the molecular pathways, biomarkers and potential targets that may improve the outcome in BCa. PAGEPress Publications, Pavia, Italy 2016-12-14 /pmc/articles/PMC5178843/ /pubmed/28058098 http://dx.doi.org/10.4081/oncol.2016.320 Text en ©Copyright A.A. Mohammed et al. http://creativecommons.org/licenses/by-nc/3.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Review Mohammed, Amrallah A. EL-Tanni, Hani EL-Khatib, Hani M. Mirza, Ahmad A. Mirza, Abdulrahim A. Alturaifi, Turki H. Urinary Bladder Cancer: Biomarkers and Target Therapy, New Era for More Attention |
title | Urinary Bladder Cancer: Biomarkers and Target Therapy, New Era for More Attention |
title_full | Urinary Bladder Cancer: Biomarkers and Target Therapy, New Era for More Attention |
title_fullStr | Urinary Bladder Cancer: Biomarkers and Target Therapy, New Era for More Attention |
title_full_unstemmed | Urinary Bladder Cancer: Biomarkers and Target Therapy, New Era for More Attention |
title_short | Urinary Bladder Cancer: Biomarkers and Target Therapy, New Era for More Attention |
title_sort | urinary bladder cancer: biomarkers and target therapy, new era for more attention |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5178843/ https://www.ncbi.nlm.nih.gov/pubmed/28058098 http://dx.doi.org/10.4081/oncol.2016.320 |
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