A Rare Case of Hemophagocytic Lymphohistiocytosis Associated with Parvovirus B19 Infection

Hemophagocytic lymphohistiocytosis (HLH) is a rare but life-threatening syndrome resulting from excessive immune activation. Secondarily, HLH is often associated with autoimmune disease, infection, and malignancy. The most common infectious trigger is Epstein-Barr virus (EBV) infection. HLH is rarel...

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Autores principales: Yuan, Cai, Asad-Ur-Rahman, FNU, Abusaada, Khalid
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cureus 2016
Materias:
Internal Medicine
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5178984/
https://www.ncbi.nlm.nih.gov/pubmed/28018767
http://dx.doi.org/10.7759/cureus.897
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author Yuan, Cai
Asad-Ur-Rahman, FNU
Abusaada, Khalid
author_facet Yuan, Cai
Asad-Ur-Rahman, FNU
Abusaada, Khalid
author_sort Yuan, Cai
collection PubMed
description Hemophagocytic lymphohistiocytosis (HLH) is a rare but life-threatening syndrome resulting from excessive immune activation. Secondarily, HLH is often associated with autoimmune disease, infection, and malignancy. The most common infectious trigger is Epstein-Barr virus (EBV) infection. HLH is rarely triggered by parvovirus B19. We discuss a case of a 62-year-old male who presented with multi-organ failure with presumed septic shock who eventually was diagnosed with HLH, with positive parvovirus B19 deoxyribonucleic acid (DNA) polymerase chain reaction (PCR). Prompt treatment with dexamethasone resulted in significant clinical resolution.
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spelling pubmed-51789842016-12-23 A Rare Case of Hemophagocytic Lymphohistiocytosis Associated with Parvovirus B19 Infection Yuan, Cai Asad-Ur-Rahman, FNU Abusaada, Khalid Cureus Internal Medicine Hemophagocytic lymphohistiocytosis (HLH) is a rare but life-threatening syndrome resulting from excessive immune activation. Secondarily, HLH is often associated with autoimmune disease, infection, and malignancy. The most common infectious trigger is Epstein-Barr virus (EBV) infection. HLH is rarely triggered by parvovirus B19. We discuss a case of a 62-year-old male who presented with multi-organ failure with presumed septic shock who eventually was diagnosed with HLH, with positive parvovirus B19 deoxyribonucleic acid (DNA) polymerase chain reaction (PCR). Prompt treatment with dexamethasone resulted in significant clinical resolution. Cureus 2016-11-24 /pmc/articles/PMC5178984/ /pubmed/28018767 http://dx.doi.org/10.7759/cureus.897 Text en Copyright © 2016, Yuan et al. http://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Internal Medicine
Yuan, Cai
Asad-Ur-Rahman, FNU
Abusaada, Khalid
A Rare Case of Hemophagocytic Lymphohistiocytosis Associated with Parvovirus B19 Infection
title A Rare Case of Hemophagocytic Lymphohistiocytosis Associated with Parvovirus B19 Infection
title_full A Rare Case of Hemophagocytic Lymphohistiocytosis Associated with Parvovirus B19 Infection
title_fullStr A Rare Case of Hemophagocytic Lymphohistiocytosis Associated with Parvovirus B19 Infection
title_full_unstemmed A Rare Case of Hemophagocytic Lymphohistiocytosis Associated with Parvovirus B19 Infection
title_short A Rare Case of Hemophagocytic Lymphohistiocytosis Associated with Parvovirus B19 Infection
title_sort rare case of hemophagocytic lymphohistiocytosis associated with parvovirus b19 infection
topic Internal Medicine
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5178984/
https://www.ncbi.nlm.nih.gov/pubmed/28018767
http://dx.doi.org/10.7759/cureus.897
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