Cargando…

Drug Repositioning for Alzheimer’s Disease Based on Systematic ‘omics’ Data Mining

Traditional drug development for Alzheimer’s disease (AD) is costly, time consuming and burdened by a very low success rate. An alternative strategy is drug repositioning, redirecting existing drugs for another disease. The large amount of biological data accumulated to date warrants a comprehensive...

Descripción completa

Detalles Bibliográficos
Autores principales:	Zhang, Ming, Schmitt-Ulms, Gerold, Sato, Christine, Xi, Zhengrui, Zhang, Yalun, Zhou, Ye, St George-Hyslop, Peter, Rogaeva, Ekaterina
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2016
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5179106/ https://www.ncbi.nlm.nih.gov/pubmed/28005991 http://dx.doi.org/10.1371/journal.pone.0168812

Ejemplares similares

Drug Repositioning for Diabetes Based on 'Omics' Data Mining
por: Zhang, Ming, et al.
Publicado: (2015)

The Prion Protein Controls Polysialylation of Neural Cell Adhesion Molecule 1 during Cellular Morphogenesis
por: Mehrabian, Mohadeseh, et al.
Publicado: (2015)

A ZIP6-ZIP10 heteromer controls NCAM1 phosphorylation and integration into focal adhesion complexes during epithelial-to-mesenchymal transition
por: Brethour, Dylan, et al.
Publicado: (2017)

Time-course global proteome analyses reveal an inverse correlation between Aβ burden and immunoglobulin M levels in the APP(NL-F) mouse model of Alzheimer disease
por: Wang, Hansen, et al.
Publicado: (2017)

Genome-Wide Survey of Large Rare Copy Number Variants in Alzheimer’s Disease Among Caribbean Hispanics
por: Ghani, Mahdi, et al.
Publicado: (2012)

Somatostatin in Alzheimer's disease: A new Role for an Old Player
por: Solarski, Michael, et al.
Publicado: (2018)

TMP21 Transmembrane Domain Regulates γ-Secretase Cleavage
por: Pardossi-Piquard, Raphaëlle, et al.
Publicado: (2009)

Structural biology of presenilin 1 complexes
por: Li, Yi, et al.
Publicado: (2014)

Mining integrated semantic networks for drug repositioning opportunities
por: Mullen, Joseph, et al.
Publicado: (2016)

Drug repositioning for dengue haemorrhagic fever by integrating multiple omics analyses
por: Amemiya, Takayuki, et al.
Publicado: (2019)

Pathway Analysis for Drug Repositioning Based on Public Database Mining
por: Pan, Yongmei, et al.
Publicado: (2014)

Drug Repositioning in the Mirror of Patenting: Surveying and Mining Uncharted Territory
por: Mucke, Hermann A. M.
Publicado: (2017)

MicroRNA‐128 suppresses tau phosphorylation and reduces amyloid‐beta accumulation by inhibiting the expression of GSK3β, APPBP2, and mTOR in Alzheimer's disease
por: Li, Siwen, et al.
Publicado: (2023)

Drug Repositioning through Systematic Mining of Gene Coexpression Networks in Cancer
por: Ivliev, Alexander E., et al.
Publicado: (2016)

HeTDR: Drug repositioning based on heterogeneous networks and text mining
por: Jin, Shuting, et al.
Publicado: (2021)

Prevention of Alzheimer's disease in high risk groups: statin therapy in subjects with PSEN1 mutations or heterozygosity for apolipoprotein E epsilon 4
por: Pollen, Daniel A, et al.
Publicado: (2010)

Combined epigenetic/genetic study identified an ALS age of onset modifier
por: Zhang, Ming, et al.
Publicado: (2021)

Target RNA modification for epigenetic drug repositioning in neuroblastoma: computational omics proximity between repurposing drug and disease
por: Ma, Pei, et al.
Publicado: (2020)

The Intersection between COVID-19, the Gene Family of ACE2 and Alzheimer’s Disease
por: Haghighi, Mahdi Montazer, et al.
Publicado: (2020)

Rare coding mutations identified by sequencing of Alzheimer disease genome‐wide association studies loci
por: Vardarajan, Badri N., et al.
Publicado: (2015)

Drug repositioning targeting glutaminase reveals drug candidates for the treatment of Alzheimer’s disease patients
por: Bayraktar, Abdulahad, et al.
Publicado: (2023)

Drug Repositioning: An Opportunity to Develop Novel Treatments for Alzheimer’s Disease
por: Corbett, Anne, et al.
Publicado: (2013)

β-Secretase-1: In Silico Drug Reposition for Alzheimer’s Disease
por: Galeana-Ascencio, Roberto A., et al.
Publicado: (2023)

An emerging role of the cellular prion protein as a modulator of a morphogenetic program underlying epithelial-to-mesenchymal transition
por: Mehrabian, Mohadeseh, et al.
Publicado: (2014)

NCAM1 Polysialylation: The Prion Protein's Elusive Reason for Being?
por: Mehrabian, Mohadeseh, et al.
Publicado: (2016)

The Evolutionary unZIPping of a Dimerization Motif—A Comparison of ZIP and PrP Architectures
por: Hu, Jian, et al.
Publicado: (2017)

APOE ε4, white matter hyperintensities, and cognition in Alzheimer and Lewy body dementia
por: Mirza, Saira Saeed, et al.
Publicado: (2019)

DNA methylation age acceleration is associated with ALS age of onset and survival
por: Zhang, Ming, et al.
Publicado: (2020)

Application of multiple omics and network projection analyses to drug repositioning for pathogenic mosquito-borne viruses
por: Amemiya, Takayuki, et al.
Publicado: (2021)

Systematic drug repositioning through mining adverse event data in ClinicalTrials.gov
por: Su, Eric Wen, et al.
Publicado: (2017)

A Systematic Framework for Drug Repositioning from Integrated Omics and Drug Phenotype Profiles Using Pathway-Drug Network
por: Jadamba, Erkhembayar, et al.
Publicado: (2016)

Adopting Text Mining on Rehabilitation Therapy Repositioning for Stroke
por: Meng, Guilin, et al.
Publicado: (2019)

Inbreeding among Caribbean Hispanics from the Dominican Republic and the Effects on the Risk of Alzheimer's Disease
por: Vardarajan, BN, et al.
Publicado: (2014)

Robust Sampling of Defective Pathways in Alzheimer’s Disease. Implications in Drug Repositioning
por: Fernández-Martínez, Juan Luis, et al.
Publicado: (2020)

A Proteotranscriptomic-Based Computational Drug-Repositioning Method for Alzheimer’s Disease
por: Lee, Soo Youn, et al.
Publicado: (2020)

PharmOmics: A species- and tissue-specific drug signature database and gene-network-based drug repositioning tool
por: Chen, Yen-Wei, et al.
Publicado: (2022)

Repositioning Drugs for Psychiatry
por: Akhondzadeh, Shahin
Publicado: (2020)

Does Soluble TREM2 Protect Against Alzheimer's Disease?
por: Brown, Guy C., et al.
Publicado: (2022)

Repositioned Drugs for Chagas Disease Unveiled via Structure-Based Drug Repositioning
por: Adasme, Melissa F., et al.
Publicado: (2020)

Drug repositioning in drug discovery of T2DM and repositioning potential of antidiabetic agents
por: Zhu, Sha, et al.
Publicado: (2022)

Cannot write session to /tmp/vufind_sessions/sess_nl7h4jtri73u3lhfqh9o7f9kdf