Hypoxia drives the transition of human dermal fibroblasts to a myofibroblast-like phenotype via the TGF-β1/Smad3 pathway

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Keloids, partially considered as benign tumors, are characterized by the overgrowth of fibrosis beyond the boundaries of the wound and are regulated mainly by transforming growth factor (TGF)-β1, which induces the transition of fibroblasts to myofibroblasts. Hypoxia is an important driving force in...

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Detalles Bibliográficos
Autores principales: Zhao, Bin, Guan, Hao, Liu, Jia-Qi, Zheng, Zhao, Zhou, Qin, Zhang, Jian, Su, Lin-Lin, Hu, Da-Hai
Formato: Online Artículo Texto
Lenguaje:English
Publicado: D.A. Spandidos 2017
Materias:
Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5179176/
https://www.ncbi.nlm.nih.gov/pubmed/27909731
http://dx.doi.org/10.3892/ijmm.2016.2816
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