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Weight Gain and Height Growth during Infancy, Childhood, and Adolescence as Predictors of Adult Cardiovascular Risk

OBJECTIVES: To investigate independent relationships of childhood linear growth (height gain) and relative weight gain to adult cardiovascular disease (CVD) risk traits in Asian Indians. STUDY DESIGN: Data from 2218 adults from the Vellore Birth Cohort were examined for associations of cross-section...

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Autores principales: Antonisamy, Belavendra, Vasan, Senthil K., Geethanjali, Finney S., Gowri, Mahasampath, Hepsy, Y.S., Richard, Joseph, Raghupathy, P., Karpe, Fredrik, Osmond, Clive, Fall, Caroline H.D.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Mosby 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5179199/
https://www.ncbi.nlm.nih.gov/pubmed/27823768
http://dx.doi.org/10.1016/j.jpeds.2016.09.059
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author Antonisamy, Belavendra
Vasan, Senthil K.
Geethanjali, Finney S.
Gowri, Mahasampath
Hepsy, Y.S.
Richard, Joseph
Raghupathy, P.
Karpe, Fredrik
Osmond, Clive
Fall, Caroline H.D.
author_facet Antonisamy, Belavendra
Vasan, Senthil K.
Geethanjali, Finney S.
Gowri, Mahasampath
Hepsy, Y.S.
Richard, Joseph
Raghupathy, P.
Karpe, Fredrik
Osmond, Clive
Fall, Caroline H.D.
author_sort Antonisamy, Belavendra
collection PubMed
description OBJECTIVES: To investigate independent relationships of childhood linear growth (height gain) and relative weight gain to adult cardiovascular disease (CVD) risk traits in Asian Indians. STUDY DESIGN: Data from 2218 adults from the Vellore Birth Cohort were examined for associations of cross-sectional height and body mass index (BMI) and longitudinal growth (independent conditional measures of height and weight gain) in infancy, childhood, adolescence, and adulthood with adult waist circumference (WC), blood pressure (BP), insulin resistance (homeostatic model assessment-insulin resistance [HOMA-IR]), and plasma glucose and lipid concentrations. RESULTS: Higher BMI/greater conditional relative weight gain at all ages was associated with higher adult WC, after 3 months with higher adult BP, HOMA-IR, and lipids, and after 15 years with higher glucose concentrations. Taller adult height was associated with higher WC (men β = 2.32 cm per SD, women β = 1.63, both P < .001), BP (men β = 2.10 mm Hg per SD, women β = 1.21, both P ≤ .001), and HOMA-IR (men β = 0.08 log units per SD, women β = 0.12, both P ≤ .05) but lower glucose concentrations (women β = −0.03 log mmol/L per SD P = .003). Greater height or height gain at all earlier ages were associated with higher adult CVD risk traits. These positive associations were attenuated when adjusted for adult BMI and height. Shorter length and lower BMI at birth were associated with higher glucose concentration in women. CONCLUSIONS: Greater height or weight gain relative to height during childhood or adolescence was associated with a more adverse adult CVD risk marker profile, and this was mostly attributable to larger adult size.
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spelling pubmed-51791992017-01-01 Weight Gain and Height Growth during Infancy, Childhood, and Adolescence as Predictors of Adult Cardiovascular Risk Antonisamy, Belavendra Vasan, Senthil K. Geethanjali, Finney S. Gowri, Mahasampath Hepsy, Y.S. Richard, Joseph Raghupathy, P. Karpe, Fredrik Osmond, Clive Fall, Caroline H.D. J Pediatr Original Articles OBJECTIVES: To investigate independent relationships of childhood linear growth (height gain) and relative weight gain to adult cardiovascular disease (CVD) risk traits in Asian Indians. STUDY DESIGN: Data from 2218 adults from the Vellore Birth Cohort were examined for associations of cross-sectional height and body mass index (BMI) and longitudinal growth (independent conditional measures of height and weight gain) in infancy, childhood, adolescence, and adulthood with adult waist circumference (WC), blood pressure (BP), insulin resistance (homeostatic model assessment-insulin resistance [HOMA-IR]), and plasma glucose and lipid concentrations. RESULTS: Higher BMI/greater conditional relative weight gain at all ages was associated with higher adult WC, after 3 months with higher adult BP, HOMA-IR, and lipids, and after 15 years with higher glucose concentrations. Taller adult height was associated with higher WC (men β = 2.32 cm per SD, women β = 1.63, both P < .001), BP (men β = 2.10 mm Hg per SD, women β = 1.21, both P ≤ .001), and HOMA-IR (men β = 0.08 log units per SD, women β = 0.12, both P ≤ .05) but lower glucose concentrations (women β = −0.03 log mmol/L per SD P = .003). Greater height or height gain at all earlier ages were associated with higher adult CVD risk traits. These positive associations were attenuated when adjusted for adult BMI and height. Shorter length and lower BMI at birth were associated with higher glucose concentration in women. CONCLUSIONS: Greater height or weight gain relative to height during childhood or adolescence was associated with a more adverse adult CVD risk marker profile, and this was mostly attributable to larger adult size. Mosby 2017-01 /pmc/articles/PMC5179199/ /pubmed/27823768 http://dx.doi.org/10.1016/j.jpeds.2016.09.059 Text en © 2016 The Authors http://creativecommons.org/licenses/by/4.0/ This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Original Articles
Antonisamy, Belavendra
Vasan, Senthil K.
Geethanjali, Finney S.
Gowri, Mahasampath
Hepsy, Y.S.
Richard, Joseph
Raghupathy, P.
Karpe, Fredrik
Osmond, Clive
Fall, Caroline H.D.
Weight Gain and Height Growth during Infancy, Childhood, and Adolescence as Predictors of Adult Cardiovascular Risk
title Weight Gain and Height Growth during Infancy, Childhood, and Adolescence as Predictors of Adult Cardiovascular Risk
title_full Weight Gain and Height Growth during Infancy, Childhood, and Adolescence as Predictors of Adult Cardiovascular Risk
title_fullStr Weight Gain and Height Growth during Infancy, Childhood, and Adolescence as Predictors of Adult Cardiovascular Risk
title_full_unstemmed Weight Gain and Height Growth during Infancy, Childhood, and Adolescence as Predictors of Adult Cardiovascular Risk
title_short Weight Gain and Height Growth during Infancy, Childhood, and Adolescence as Predictors of Adult Cardiovascular Risk
title_sort weight gain and height growth during infancy, childhood, and adolescence as predictors of adult cardiovascular risk
topic Original Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5179199/
https://www.ncbi.nlm.nih.gov/pubmed/27823768
http://dx.doi.org/10.1016/j.jpeds.2016.09.059
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