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The Mitotic Checkpoint Complex Requires an Evolutionary Conserved Cassette to Bind and Inhibit Active APC/C

The Spindle Assembly Checkpoint (SAC) ensures genomic stability by preventing sister chromatid separation until all chromosomes are attached to the spindle. It catalyzes the production of the Mitotic Checkpoint Complex (MCC), which inhibits Cdc20 to inactivate the Anaphase Promoting Complex/Cyclosom...

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Detalles Bibliográficos
Autores principales:	Di Fiore, Barbara, Wurzenberger, Claudia, Davey, Norman E., Pines, Jonathon
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Cell Press 2016
Materias:	Short Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5179498/ https://www.ncbi.nlm.nih.gov/pubmed/27939943 http://dx.doi.org/10.1016/j.molcel.2016.11.006

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