Cargando…
Neuroendocrine and Peptidergic Regulation of Stress-Induced REM Sleep Rebound
Sleep homeostasis depends on the length and quality (occurrence of stressful events, for instance) of the preceding waking time. Forced wakefulness (sleep deprivation or sleep restriction) is one of the main tools used for the understanding of mechanisms that play a role in homeostatic processes inv...
Autores principales: | , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2016
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5179577/ https://www.ncbi.nlm.nih.gov/pubmed/28066328 http://dx.doi.org/10.3389/fendo.2016.00163 |
_version_ | 1782485367084023808 |
---|---|
author | Machado, Ricardo Borges Suchecki, Deborah |
author_facet | Machado, Ricardo Borges Suchecki, Deborah |
author_sort | Machado, Ricardo Borges |
collection | PubMed |
description | Sleep homeostasis depends on the length and quality (occurrence of stressful events, for instance) of the preceding waking time. Forced wakefulness (sleep deprivation or sleep restriction) is one of the main tools used for the understanding of mechanisms that play a role in homeostatic processes involved in sleep regulation and their interrelations. Interestingly, forced wakefulness for periods longer than 24 h activates stress response systems, whereas stressful events impact on sleep pattern. Hypothalamic peptides (corticotropin-releasing hormone, prolactin, and the CLIP/ACTH(18–39)) play an important role in the expression of stress-induced sleep effects, essentially by modulating rapid eye movement sleep, which has been claimed to affect the organism resilience to the deleterious effects of stress. Some of the mechanisms involved in the generation and regulation of sleep and the main peptides/hypothalamic hormones involved in these responses will be discussed in this review. |
format | Online Article Text |
id | pubmed-5179577 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2016 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-51795772017-01-06 Neuroendocrine and Peptidergic Regulation of Stress-Induced REM Sleep Rebound Machado, Ricardo Borges Suchecki, Deborah Front Endocrinol (Lausanne) Endocrinology Sleep homeostasis depends on the length and quality (occurrence of stressful events, for instance) of the preceding waking time. Forced wakefulness (sleep deprivation or sleep restriction) is one of the main tools used for the understanding of mechanisms that play a role in homeostatic processes involved in sleep regulation and their interrelations. Interestingly, forced wakefulness for periods longer than 24 h activates stress response systems, whereas stressful events impact on sleep pattern. Hypothalamic peptides (corticotropin-releasing hormone, prolactin, and the CLIP/ACTH(18–39)) play an important role in the expression of stress-induced sleep effects, essentially by modulating rapid eye movement sleep, which has been claimed to affect the organism resilience to the deleterious effects of stress. Some of the mechanisms involved in the generation and regulation of sleep and the main peptides/hypothalamic hormones involved in these responses will be discussed in this review. Frontiers Media S.A. 2016-12-23 /pmc/articles/PMC5179577/ /pubmed/28066328 http://dx.doi.org/10.3389/fendo.2016.00163 Text en Copyright © 2016 Machado and Suchecki. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Endocrinology Machado, Ricardo Borges Suchecki, Deborah Neuroendocrine and Peptidergic Regulation of Stress-Induced REM Sleep Rebound |
title | Neuroendocrine and Peptidergic Regulation of Stress-Induced REM Sleep Rebound |
title_full | Neuroendocrine and Peptidergic Regulation of Stress-Induced REM Sleep Rebound |
title_fullStr | Neuroendocrine and Peptidergic Regulation of Stress-Induced REM Sleep Rebound |
title_full_unstemmed | Neuroendocrine and Peptidergic Regulation of Stress-Induced REM Sleep Rebound |
title_short | Neuroendocrine and Peptidergic Regulation of Stress-Induced REM Sleep Rebound |
title_sort | neuroendocrine and peptidergic regulation of stress-induced rem sleep rebound |
topic | Endocrinology |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5179577/ https://www.ncbi.nlm.nih.gov/pubmed/28066328 http://dx.doi.org/10.3389/fendo.2016.00163 |
work_keys_str_mv | AT machadoricardoborges neuroendocrineandpeptidergicregulationofstressinducedremsleeprebound AT sucheckideborah neuroendocrineandpeptidergicregulationofstressinducedremsleeprebound |