A reduction in Drp1-mediated fission compromises mitochondrial health in autosomal recessive spastic ataxia of Charlevoix Saguenay

The neurodegenerative disease autosomal recessive spastic ataxia of Charlevoix Saguenay (ARSACS) is caused by loss of function of sacsin, a modular protein that is required for normal mitochondrial network organization. To further understand cellular consequences of loss of sacsin, we performed micr...

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Detalles Bibliográficos
Autores principales: Bradshaw, Teisha Y., Romano, Lisa E.L., Duncan, Emma J., Nethisinghe, Suran, Abeti, Rosella, Michael, Gregory J., Giunti, Paola, Vermeer, Sascha, Chapple, J. Paul
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2016
Materias:
Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5179924/
https://www.ncbi.nlm.nih.gov/pubmed/27288452
http://dx.doi.org/10.1093/hmg/ddw173

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